Insight on Genotoxicity

This book examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development. Genetic toxicity mechanism has also been discussed in detail with a wider perspective.

Genetic toxicity testing has been discussed with sub sections taking in to consideration the performance enhancing of in vitrogenotoxicity testing. Book defines appropriate strategies about advances in in vivogenotoxicity testing which have been listed along with progress and future prospects. High-throughput approaches for genotoxicity testing in drug development and pertaining recent advances have been mentioned in sections. Computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development have been discussed in detail. The Allium cepa test which is the bioindicator of genotoxicity has also been discussed in wide.

In the last section genotoxicity assessment of nano sized material/particles has been mentioned as a part of recent advancement.