This book examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development. Genetic toxicity mechanism has also been discussed in detail with a wider perspective. Genetic toxicity testing has been discussed with sub sections taking in to consideration the performance enhancing of in vitrogenotoxicity testing. Book defines appropriate strategies about advances in in vivogenotoxicity testing which have been listed along with progress and future prospects. High-throughput approaches for genotoxicity testing in drug development and pertaining recent advances have been mentioned in sections. Computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development have been discussed in detail. The Allium cepa test which is the bioindicator of genotoxicity has also been discussed in wide. In the last section genotoxicity assessment of nano sized material/particles has been mentioned as a part of recent advancement.

Insight on Genotoxicity

Science & Math

Pandey, Ravindra Kumar

Shukla, Shiv Shankar

Gidwani, Bina

Kalyani, Gunjan

Chemistry

CRC-Press

Due to the increase in the consumption of herbal medicine, there is a need to know which scientifically based methods are appropriate for assessing the quality of herbal medicines. Fingerprinting has emerged as a suitable technique for quality estimation. Chemical markers are used for evaluation of herbal medicines. Identification and quantification of these chemical markers are crucial for quality control of herbal medicines. This book provides updated knowledge on methodology, quality assessment, toxicity analysis and medicinal values of natural compounds.

Fingerprinting Analysis and Quality Control Methods of Herbal Medicines

Health, Fitness & Dieting

Vyas, Amber

Jain, Vishal

Alternative Medicine

Pharmaceutical Calibration, Validation and Qualification: A Comprehensive Approach

Gidwani, Beena

Springer

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Books by Pandey, Ravindra Kumar