Inhibitors of Ribonucleoside Diphosphate Reductase Activity (International Encyclopedia of Pharmacology and Therapeutics, Section 128)

The replication of DNA prior to cell division requires the process of deoxyribonucleoside triphosphate substrates for DNA polymerase. The enzyme which catalyzes the formation of deoxyribonucleotide is referred to as ribonucleotide reductase. The purpose of this volume is to review studies dealing with the ribonucleotide reductase in prokaryotic and eukaryotic cells and factors which may be involved in the control of deoxyribonucleotide formation in mammalian cells, including the use of inhibitors of ribonucleotide reductase in relation to anti-tumor chemotherapy.