<p>The replication of DNA prior to cell division requires the process of deoxyribonucleoside triphosphate substrates for DNA polymerase. The enzyme which catalyzes the formation of deoxyribonucleotide is referred to as ribonucleotide reductase. The purpose of this volume is to review studies dealing with the ribonucleotide reductase in prokaryotic and eukaryotic cells and factors which may be involved in the control of deoxyribonucleotide formation in mammalian cells, including the use of inhibitors of ribonucleotide reductase in relation to anti-tumor chemotherapy.</p>

Inhibitors of Ribonucleoside Diphosphate Reductase Activity (International Encyclopedia of Pharmacology and Therapeutics, Section 128)

Reference

Cory, Joseph G.

Encyclopedias & Subject Guides

Pergamon Pr

In anticipation of the opening of the H. Lee Moffitt Cancer Center and Research lnstitut~ on the campus of the University of South Florida, an international symposium, "The First Annual H. Lee Moffitt Symposium on Cancer Biology and Therapeutics" was held in Tampa, Florida on January 20-22, 1986. In this first symposium we decided to present a broad-based series of topics dealing with the major issues in the field of cancer. These topics ranged from the biochemistry of the cancer cell to the design of antineoplastic agents, through tumor cell heterogeneity, treatment of ltuman neoplasms to immunological aspects of cancer biology and tr~atment. The speakers chosen represented individuals of international acclaim who are very active in the area of cancer research and treatment. The symposium brought together scien tists/physicians from six nations including Austria, Canada, France, Hungary, West Germany, and of course, the United States. The congeniality of the participants promoted the friendly exchange of knowledge which, it is hoped, will greatly hasten the time when successful management of human cancer will become routine. Future symposia in this series will be highly focused and will deal with a single facet of this vast field of cancer research and treatment. Joseph G. Cory, Editor Andor Szentivanyi, Editor University of South Florida, 1986 V ACKNOWLEDGMENTS This volume presents the Proceedings of the H. Lee Moffitt International Syn~osium on Cancer Biology and Therapeutics which was held in Tampa, Florida on January 20, 21, and 22, 1986.

Cancer Biology and Therapeutics

Medical Books

Szentivanyi, A.

Research

Springer

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