Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.

Science & Math

Lacy, Charles F.

Howie, Alexander J.

Goldman, Morton P.

Lance, Leonard L.

FRIEDMAN, HERMAN

Weisman

Katz, Lynda J.

Goldstein, Gerald

Beers, Sue R.

Young, David B.

Honeyman, Allen

Lajtha, Able

Bendinelli, Mauro

Newland, Robert

Biological Sciences

Springer

...contains useful info on 1340 commonly- and not so commonly-used drugs...the drug info section is presented in a consisten format that covers up to eight points of data, and the Indications Index lists drugs for specific diseases.

Quick Look Drug Book 1996

Medical Books

Medicine

Williams Wilkins

...contains useful info on 1340 commonly- and not so commonly-used drugs...the drug info section is presented in a consisten format that covers up to eight points of data, and the Indications Index lists drugs for specific diseases.

Quick Look Drug Book, 1997

Lacy, Charles

Pharmacology

Williams and Wilkins

Quick Look Electronic Drug Reference 2006

Quick Look Electronic Drug Reference 2006 contains all the features of Quick Look Drug Book 2006 including thousands of trade and generic drug names in an easy-to-use electronic format—plus audio pronunciations, keyword/therapeutic category index, quick cross-referencing, and full-color images of the top 200 prescribed drugs. Versatile search functions allow searching the index, searching the full content, searching within a previous search, or searching on part of a word (ex: *mide finds all drug names ending with "mide"). Four-way viewing lists information by generic and trade name, generic only, "sound-alike" drugs, or user-added topics. Add-a-topic lets you add drug names to the A-to-Z index. Add-a-note lets you annotate an existing drug topic. Bookmarks allow you to create a list of frequently referenced drug topics. Windows Compatible

Health, Fitness & Dieting

Reference

Lippincott, Williams, & Wilkins

The new edition provides quick access to thousands of drug names. Designed for medical language specialists and related health professionals, each main entry includes generic name, pronunciation guide, brand names, synonyms, therapeutic category, use, usual dosage and dosage forms. Drugs are listed alphabetically and are extensively cross-referenced; the reference section consists of 16 appendices. The Indication/Therapeutic Category Index is a unique feature that allows the user to look up a medical condition to see what drugs are used for treatment. Updated information is included for 2004 drugs. The CD-ROM has full-color images of the top 200 prescribed drugs for super-fast reference.

Encyclopedias & Subject Guides

Quick Look Electronic Drug Reference 2007 contains all the features of Quick Look Drug Book 2007 including thousands of trade and generic drug names in an easy-to-use electronic format—plus audio pronunciations, keyword/therapeutic category index, quick cross-referencing, and full-color images of the top 200 prescribed drugs. Versatile search functions include A-Z index browsing, searching by keyword, searching within a previous search, or Wildcard searching by entering an asterisk as the first character in the search field (ex: *mide finds all drug names ending with "mide"). Four-way viewing lists information by generic and trade name, generic only, "sound-alike" drugs, or user-added topics. Add-a-topic lets you add drug names to the A-to-Z index. Add-a-note lets you annotate a topic. You can also bookmark frequently referenced topics. Windows Compatible

Quick Look Electronic Drug Reference 2007

Quick Look Drug Book 2008

Armstrong, Lora L.

Goodman, Morton P.

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Quick Look Drug Book

Quick Look Drug Book 2009 includes the most current information on thousands of commonly used drugs, plus a 32-page color insert showing the 200 most commonly prescribed medications. Medical transcriptionists and other healthcare professionals rely on this comprehensive resource for information on brand and generic drug names, pronunciations, look-alike/sound-alike issues, therapeutic categories, dosages, and dosage forms. Exclusive to Quick Look Drug Book is the Indication/Therapeutic Category Index that lists conditions/diseases alphabetically with the drugs used to treat them. Updates include new drugs introduced or approved by the FDA in 2008. Nine appendices are included. The CD-ROM version has search functions that allow super-fast reference. See CD-ROM listing for details on Quick Look Electronic Drug Reference 2009.

Quick Look Drug Book 2009

...compiled specifically for the health care professional who needs quick access to concisely stated drug information ...covers 975 medications that have up to 24 key fields of data.

Drug Information Handbook, 1996-97 (DRUG INFORMATION HANDBOOK FOR THE ALLIED HEALTH PROFESSIONAL)

Ingrim, Naomi

Nursing

Lexi-Comp, Inc.

See the best price to sell, buy, or rent books by Lance, Leonard L.. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Lance, Leonard L.