Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.

Science & Math

Lacy, Charles F.

Howie, Alexander J.

Goldman, Morton P.

Lance, Leonard L.

FRIEDMAN, HERMAN

Weisman

Katz, Lynda J.

Goldstein, Gerald

Beers, Sue R.

Young, David B.

Honeyman, Allen

Lajtha, Able

Bendinelli, Mauro

Newland, Robert

Biological Sciences

Springer

...contains useful info on 1340 commonly- and not so commonly-used drugs...the drug info section is presented in a consisten format that covers up to eight points of data, and the Indications Index lists drugs for specific diseases.

Quick Look Drug Book, 1997

Medical Books

Lacy, Charles

Pharmacology

Williams and Wilkins

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Quick Look Drug Book

Armstrong, Lora L.

Medicine

Lippincott, Williams, & Wilkins

Quick Look Drug Book 2009 includes the most current information on thousands of commonly used drugs, plus a 32-page color insert showing the 200 most commonly prescribed medications. Medical transcriptionists and other healthcare professionals rely on this comprehensive resource for information on brand and generic drug names, pronunciations, look-alike/sound-alike issues, therapeutic categories, dosages, and dosage forms. Exclusive to Quick Look Drug Book is the Indication/Therapeutic Category Index that lists conditions/diseases alphabetically with the drugs used to treat them. Updates include new drugs introduced or approved by the FDA in 2008. Nine appendices are included. The CD-ROM version has search functions that allow super-fast reference. See CD-ROM listing for details on Quick Look Electronic Drug Reference 2009.

Quick Look Drug Book 2009

Health, Fitness & Dieting

Reference

...updated to include information on new drugs as well as updated monographs and appendices...with Canadian and Mexican brand names, test interactions, nursing implications, dietary considerations, and outstanding cross-referencing.

Drug Information Handbook: Pocket, 1999-2000

Nursing

Lexi-Comp, Inc.

This handbook is specifically compiled and designed for the healthcare professional requiring quick access to concisely stated comprehensive data concerning the clinical use of medications.

Drug Information Handbook

Nevada College of Pharmacy, Las Vegas. Annual reference is the pocket-sized edition of the text of the same title, listed in week 2004-12. Features more than 1,300 drug monographs with numerous fields of information for each. Softcover.

Drug Information Handbook: 2004-2005

Covers over 1339 Drug Monographs. Drug Interaction information is separated into the following: Cytochrome P450 Effect, Increased Effect/Toxicity, Decreased Effect, and Ethanol/Nutritional/Herb Interactions.

Lexi Comp's Drug Information Handbook (DRUG INFORMATION SERIES)

This comprehensive, integrated, and easy-to-use handbook was designed to meet the needs of healthcare professionals involved in the diagnosis and treatment of patients with infectious diseases.

Infectious Diseases Handbook: Including Antimicrobial Therapy & Diagnostic Tests/Procedures -- 6th Edition (Diagnostic Medicine Series)

Aberg, Judith A.

Gray, Larry D., Ph.D.

Long, Jennifer K.

Lexi-Comp's Drug Information Handbook continues to set the industry standard with hundreds of thousands of copies sold! This easy to use reference is a must-have for all clinicians and healthcare professionals seeking quick access to concise, comprehensive drug information. This book contains over 1400 monographs, including 30 new drugs and hundreds of updates. Each monograph encompasses up to 33 fields of information, with very detailed content on dosage, drug interactions, and adverse reactions. With this edition, US Black Box Warnings are highlighted within the monographs. Supplementing the drug information is an extensive Appendix, with hundreds of charts and reviews of special topics, such as treatment guidelines and therapy recommendations. Also included is a Pharmacologic Category Index, listing all drugs in this handbook under their unique pharmacologic class.

Drug Information Handbook: A Comprehensive Resource for All Clinicians and Healthcare Professionals (Lexi Comp's Drug Information Handbooks)

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