The papers collected in this volume were presented at the 4th International Symposium on Mass Spectrometry in Biochemistry and Medicine held at Riva del Garda, Italy in June 1977. This meeting was organised by the Italian Group for Mass Spectrometry in Biochemistry and Medicine. The group was founded in Milan, Italy, in 1975 by researchers working in different fields (chemistry, pharmacology, medicine, biology). The aim of the symposium was to bring together people working in different branches of mass spectrometry for mutual discussion, exchange of ideas and experience. I wish to thank Mrs. Judy Baggot, Mrs. Donata Castoldi and Miss Vanna Pistotti for their invaluable technical assistance and countless efforts in the preparation of this volume. Alberto Frigerio Milan, January, 1978 v CONTENTS Newer Aspects of the Biotransformation of Carbamazepine: Structural Characterization of Highly Polar Metabolites • • • • 1 W. J. Richter, P. Kriemler and J. W. Faigle Distribution in Brain Areas of Carbamazepine and Carbamazepine-lO,ll-epoxide in 6-Hydroxydopamine Pretreated Rats 15 C. Pantarotto, V. Crunelli, A. Quattrone, P. Negrini, A. Frigerio and R. Samanin Specific Ion Detection of Aryloxy Beta Blocking Drugs for Metabolic Fate Determinations Applications to Alprenolol in Rats and Dogs 29 T. Walle and K. Walle The Use of GC-MS in Perinatal Pharmacology: The Metabolism and Pharmacokinetics of Analgesic Drugs in Mothers and Their Babies • • • • • • • • 49 J. Caldwell, L. J. Notarianni and L. A.

Recent Developments in Mass Spectrometry in Biochemistry and Medicine: Volume 1

Alberto FRIGERIO

Medical Books

Springer

The papers collected in this volume were presented at the 5th International Symposium on Mass Spectrometry in Biochemistry and Medicine held at Rimini, Italy, in June 1978. This meeting was organized by the Italian Group for Mass Spectrometry in Biochemistry and Medicine, which was founded in Milan, Italy, in 1975 by researchers working in different fields (chemistry, pharmacology, medicine, biology). I wish to thank Mrs. Anna Bernard, Mrs. Donata Castoldi and Miss Vanna Pistotti for their invaluable technical assistance and countless eff. orts in the preparation of this volume. Alberto Frigerio Milan, March, 1979 v Contents The Place of Mass Spectrometry in Drug Metabolism Studies ...1 A. Benakis In Vitro and in vivo Studies on the Metabolism of Dibenzo/c,f 7-/-1,2 7 Diazepine ********. ********* 9 A. Frigerio, P~ Negrini, D~ Rotilio, A. De Pascale and E. Rossi Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat 27 L. Simonotti, R. Colombo and G. Pifferi Mass Spectrometric Characterization of Sydnocarb ~ and its Major Metabolites in Rat ***************** 43 J. Tamas, M. Polgar, G. Czira and L. Vereczkey Metabolism of an Aryloxy Beta Blocking Drug 53 G. L. Passetti, E. Grassi and A. Trebbi Isolation and Identification of the Chloroform Soluble Urinary Metabolites of Suloctidil in Man . ****. . ** 69 R. Roncucci, W. Cautreels, M. Martens, C. Gillet, K. Debast and G. Lambelin Are Stable Sulfenic Acids Possible Metabolites of Suloctidil? ...85 W. Cautreels, M. Martens, R. Roncucci, C. Gillet, K. Debast and G.

Recent Developments in Mass Spectrometry in Biochemistry and Medicine: Volume 2

Science & Math

Biological Sciences

Recent developments in chromatography and electrophoresis, 10: Proceedings of the 10th International Symposium on Chromatography and Electrophoresis, ... 1979 (Analytical chemistry symposia series)

Elsevier Scientific Publishing Company

Advances in Mass Spectrometry in Biochemistry and Medicine, Vol. 1

Halsted Press

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Books by Alberto FRIGERIO