<p>There is great interest in using serum free light chain measurements alongside serum protein electrophoresis  o screen symptomatic patients  for monoclonal  gammopathies. The strategy is more sensitive than testing for Bence Jones proteinuria: both simpler and clinically more accurate, Many centres are now using the test in this manner, leading to improvements in patient diagnosis and management. Support  for this approach is seen in the emerging International Guidelines for treating patients with multiple myeloma and AI. amyloidosis. Uniform Response criteria have been  defined, and patients previously thought to have nonsecretory disease can now enter clinical trials.  The full impact of the Free light chains as fast response markers in therapy is yet to be realized. But, in some centres, failure of serum free light chain concentrations to fall rapidly following treatment alterations is interpreted as therapeutic failure. Drug doses of regimens are altered accordingly and ineffective chemotherapy terminated.</p>

Serum Free Light Chain Analysis

A.R. Bradwell

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Serum Free Light Chain Analysis