In the past few years the transplantation of organs in man has received publicity unprecedented in medical history. The first heart grafts were covered by press, radio, and television on a scal~ equiva lent to the news of the outbreak of a major war. Unwarranted and extravagant optimism has been followed by bitter criticism. This has undermined public confidence in the medical profession and seriously impeded progress in an important endeavour aimed at reducing human suffering. This unfortunate situation has arisen from widespread ignorance amongst the public and the medical profession of the background, present achievements, and future potential of organ grafting. Short statements by experts, frequently misquoted or cut short by television interviewers, and misinformed derogatory pronouncements by prejudiced medically qualified men, with no knowledge of the field, have produced a sorry state of confusion. It is the purpose of this book to attempt to clarify organ transplantation. The principles of organ transplantation are common to all organs but I will confine most of the discussion to transplantation of four vital organs, namely the kidney, liver, heart, and lung. ROY CALNE Cambridge January 1970 CONTENTS Preface IX List of Illustrations Xlll Acknowledgements XVll I. THE IDEA I II. THE SURGERY 7 III. REJECTION 15 IV. PREVENTION OF REJECTION 23 v. TISSUEMATCHING 39 VI. ORGAN PRESERVATION 47 VII. SUITABLE DONORS 53 VIII. ORGAN TRANSPLANTS 57 IX. ETHICS AND THE LAW 81 X.

A Gift of Life: Observations on Organ Transplantation

Calne, Roy

Health, Fitness & Dieting

Throughout the history of mankind from primitive man to the present time, vitamin ddiciencies have been a major cause of death and disease. Pellagra, scurvy and beri-beri have decimated armies, ships' crews and even nations (Figure I). As late as 1925 the disease 'pernicious' anaemia caused by the ab sence of vitamin Bl2 within a person's body really lived up to its name. Although there were isolated instances of recognition of dietary deficien cies even a thousand years ago, the importance of dietary factors in the gene sis of these diseases was more widely recognized from the eighteenth century onwards and it was not until this century that the chemical structure of these factors was determined and the substances themselves synthesized. As the science of biochemistry has developed it has been found that the clinical manifestations of vitamin deficiency follow derangement of multiple metabolic functions. The majority of the vitamins in fact form specific co-en zymes in various chemical processes but at least one is converted within the body into a hormone. The commercial extraction and synthesis of the vitamins, which began mainly in the 1930S and 1940s, produced adequate quantities for a relief of vitamin detlciency diseases. The use of vitamins then became fashionable and dramatic cures were claimed for an ever increasing number of diseases.

A Guide to the Vitamins: Their Role in Health and Disease

Marks, John

Grasmere Sports: The First 150 Years

History

Roy Lomas

Europe

<p>When alarms go off aboard the USS Nimitz, first responder Kate Conrad runs to the scene of accidents and injuries. But after 93 days at sea, Kate is suspicious about strange activities in the ship's morgue, so she conducts her own gossipy investigation. Captain Fox, obsessed with the success of the ship's experimental cloaking system, delegates authority over the crew to his executive officer, Captain Brandt. And Brandt, of course, is a psychopath who coerces the ship's medical officer to cover up the problems in the morgue. As the ship approaches the equator, where the crew will hold an ancient hazing ritual, Kate Conrad confronts her superiors with proof of the horrifying activities taking place in the morgue. But they provide no help, so Kate takes drastic action on her own.</p>

Sailors Take Warning

Literature & Fiction

Torres, Malcolm

Genre Fiction

<p>Jean Oinen, haunted by a poor decision in her past, decides to rectify her mistake and set a new course for her future. She makes two phone calls that spiral into tragedy and leave the Pine County sheriff's department with a few scant clues to the events leading to her disappearance. Is this truly a murder, or has Jean cleverly managed to break the cycle of poor choices that has trapped her?Ann Skinner, contributing writer to the Hugonian wrote, "This is why I enjoyed Hooker so much; not only for its compelling drama and likable characters, and the array of technical detail, but the plot spoke to me on many levels. One of my favorite levels is surprise. What I assumed would be a simple crime novel would be something that made me think long after I had finished reading, wishing I had someone to discuss it with."</p>

Hooker: A Pine County Mystery (Pine County mysteries)

Mystery, Thriller & Suspense

Hovey, Dean L.

Mystery

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