Pathology of Tumours in Laboratory Animals (Iarc Scientific Publication)

The series Pathology of Tumours in Laboratory Animals was initiated by the International Agency for Research on Cancer 25 years ago, to provide experimental pathologists with a comprehensive, coherent source of reference information, for use in chronic toxicology research. The first edition of the volume describing tumors of the mouse was issued in 1979. Since then many papers describing new models, new methods of induction, immunohistochemical methods, or important new details of old models have been published and efforts have been made to incorporate these data wherever possible. Each chapter deals with tumors of a particular organ or system and describes all neoplasms that have been reported to occur in the organ concerned, using the terminology proposed by WHO for human tumors. The structure adopted for each chapter in the first edition (normal structure of the organ in question, classification, morphology and histology of tumors, incidence of spontaneous tumors, methods of inductions, comparative aspects, illustrations and references) is retained in the new edition. Separate chapters are included in the second edition of this volume on tumors of the nasal cavities and tumors of the salivary and lacrimal glands; in the first edition these were described in one chapter. Likewise, the chapter on tumors of hematopoietic organs is now divided into two independent chapters, one on tumors of the lymphohematopoietic tissue and the other describing histolytic sarcoma. A brief chapter on gallbladder tumors has been added.