Molecular Biology and Pharmacology of the Endothelins (Molecular Biology Intelligence Unit)

Although there is much about the endothelin system that remains to be understood, its basic molecular biology and pharmacology is now well established and there are clear indications that the endothelins are involved in both the physiological regulation of the cardiovascular system and in the pathophysiology of cardiovascular disease. This book provides a current update of the molecular biology and pharmacology of the endothelins and indicates the therapeutic areas for which the development of inhibitors of endothelin production, or antagonists at endothelin receptors, are likely to prove fruitful.