Pharmacogenomics: Applications to Patient Care

An essential resource for understanding the scientific underpinnings of this emerging discipline, Pharmacogenomics: Applications to Patient Care is designed to prepare pharmacists to integrate pharmacogenomic principles into practice.

This book contains three modules in which the basics of genetics and pharmacogenomics are described and applications to specific therapeutic areas are highlighted. Each module includes content outlines, learning objectives, key words and abstracts, self-assessment questions and explained answers, and references to reinforce learning.

Pharmacogenomics: Applications to Patient Care is available in print and online formats. Continuing pharmacy education credit is available.

Module 1: Fundamentals of Applied Human Genomics Introduces genetics and molecular and cellular biology, and how these disciplines can be used to explain the possible genetic basis for variability in drug response. Also discussed is the application of bioinformatics studies to pharmacogenomics and ethical issues in genomics.

Module 2: Fundamentals of Pharmacogenomics Introduces the pharmacogenetics of oxidative drug metabolism, along with potential applications to tailoring drug therapy. A discussion of drug transporter pharmacogenetics includes localization and function, genetic variability, and clinical consequences. Drug target pharmacogenomics and pharmacogenetics, including the role of genetic variability in drug targets on drug efficacy and toxicity, and application to individualize drug therapy are explored.

Module 3: Pharmacogenomic Applications in Patient Care Describes current and future pharmacogenomic applications for several therapeutic areas, including oncology and hematology, cardiovascular disease, infectious diseases, respiratory diseases, psychiatry, and transplantation.