Ribonucleotide Reductase Family: Genetics and Genomics: Genetics & Genomics

Ribonucleotide reductase (RNR), has a central role in DNA replication and repair by catalysing production of deoxyribonucleotides from the corresponding ribonucleotides. The authors describe a comprehensive summary of how the expression of RNR genes is regulated in several eubacterial organisms and in yeast. Due to RNR's importance for the realisation of DNA replication, it has been recognised as a possible target for antiproliferative therapy. The authors present a comprehensive summary of RNR-specific inhibitors that have reached clinical trials and/or are currently used in clinical therapy.