Ribonucleotide Reductase Family: Genetics and Genomics: Genetics & Genomics
ISBN-10:
1606924192
ISBN-13:
9781606924198
Author(s): Torrents, Eduard; Sahlin, Margareta
Edition: UK ed.
Released: May 05, 2009
Publisher: Nova Science Publishers, Inc.
Format: Hardcover, 99 pages
Related ISBN: 9781607411635
Description:
Ribonucleotide reductase (RNR), has a central role in DNA replication and repair by catalysing production of deoxyribonucleotides from the corresponding ribonucleotides. The authors describe a comprehensive summary of how the expression of RNR genes is regulated in several eubacterial organisms and in yeast. Due to RNR's importance for the realisation of DNA replication, it has been recognised as a possible target for antiproliferative therapy. The authors present a comprehensive summary of RNR-specific inhibitors that have reached clinical trials and/or are currently used in clinical therapy.
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