Oral & Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws: History, Etiology, Prevention, and Treatment

Since it was first identified in 2003, bisphosphonate-induced osteonecrosis has come under growing scrutiny by medical and dental specialists alike because it affects cancer patients receiving intravenous bisphosphonate therapy and osteoporosis patients receiving oral bisphosphonate therapy and yet its presentation of exposed bone is limited to the jaws. Based on a clear understanding of the disease mechanism and documented outcomes of the relatively small number of cases treated to date, this timely book presents definitive treatment protocols for patients who present at each stage in its progression. Equally important, it offers a simple method for predicting risk as well as crucial recommendations for steps that can be taken to prevent the disease from developing when bisphosphonate therapy is indicated. Finally, a series of comprehensive case histories related to both oral and intravenous bisphosphonates provide direct guidance in managing patients spanning the full presentation spectrum.


Contents
1. Description and History of Bisphosphonate-Induced Osteonecrosis of the Jaws

2. Modes of Action and Pharmacokinetics of the Bisphosphonate Family

3. Medical Indications for Bisphosphonates

4. Osteopetrosis: A Genetic Analogue to Bisphosphonate-Induced Osteonecrosis of the Jaws

5. Risks, Prevention, and Management of Intravenous Bisphosphonate Induced Osteonecrosis of the Jaws

6. Risks, Prevention, and Management of Oral Bisphosphonate Induced Osteonecrosis of the Jaws

7. Clinical Pathologic Case Samples

Glossary