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The Design and Analysis of Sequential Clinical Trials (Ellis Horwood Series in Mathematics and Its Applications)

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The Design and Analysis of Sequential Clinical Trials (Ellis Horwood Series in Mathematics and Its Applications) image
ISBN-10:

0470273550

ISBN-13:

9780470273555

Author(s): WHITEHEAD, John
Released: Jan 01, 1983
Publisher: Horwood Publishing Limited
Format: Paperback, 272 pages
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Description:

This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

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