The Design and Analysis of Sequential Clinical Trials (Mathematics & Its Applications)

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The Design and Analysis of Sequential Clinical Trials (Mathematics & Its Applications) image
ISBN-10:

0132025655

ISBN-13:

9780132025652

Author(s): WHITEHEAD, John
Edition: Subsequent
Released: Jan 01, 1992
Format: Hardcover

Description:

This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

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