Harrison's Principles of Internal Medicine

volume 1 of two volume set. A reference work From the preface.In the 12 edition the editors have again attempted to incorporate the latest advances in the biology,. pathophysiology, diagnosis , and treatment disease and ... build appropriate bridges between the basic sciences and and clinical medicine and emphasize the advances in medical science while retraining those facts which....remain clinically useful.It has several parts: clinical medicine, the biological basis of disease which focuses on disorders of multiple organ systems, genetic disease and diseases of the immune system.. Part two, cardinal manifestations of disease . remains the mainstays of this edition and servers as a comprehensive introduction to clinical medicine. Major patient, reviewed by organ system are correlated with specific disease states--the basis of differential diagnosis. Part Three, clinical pharmacology and P art Four, Nutrition have be reorganized. The fundamentals of clinical pharmocokinetics and individualized drug therapy are reviewed. Part V is a primarily etiologically oriented review, Infectious disease details the latest approaches to diagnosis, prevention and treatment of bacterial viral and fungal infections and parasitic infestations. A new chapter Infectious Disease and the New Biology provides major updates on host-microbe interactions, immunization, dipherea, tetanus botulism... Lyme disease, Epstein-Barr virus etc. Disorders or the organ systems which is the core of the book, includes parts six through fourteen., and include succinct accounts of the pathophysiology of major diseases. This edition includes a series of new chapters on the impact of cellular and molecular biology on the understanding of cardiovascular , pulmonary, hematologic, renal and neurologic disease. Finally Part Fifteen is an expanded and reorganized section on Environmental and Occupational hazards.