Biological systems are inherently stochastic and uncertain. Thus, research in bioinformatics, biomedical engineering and computational biology has to deal with a large amount of uncertainties. Fuzzy logic has shown to be a powerful tool in capturing different uncertainties in engineering systems. In recent years, fuzzy logic based modeling and analysis approaches are also becoming popular in analyzing biological data and modeling biological systems. Numerous research and application results have been reported that demonstrated the effectiveness of fuzzy logic in solving a wide range of biological problems found in bioinformatics, biomedical engineering, and computational biology. Contributed by leading experts world-wide, this edited book contains 16 chapters presenting representative research results on the application of fuzzy systems to genome sequence assembly, gene expression analysis, promoter analysis, cis-regulation logic analysis and synthesis, reconstruction of genetic and cellular networks, as well as biomedical problems, such as medical image processing, electrocardiogram data classification and anesthesia monitoring and control. This volume is a valuable reference for researchers, practitioners, as well as graduate students working in the field of bioinformatics, biomedical engineering and computational biology.

Fuzzy Systems in Bioinformatics and Computational Biology (Studies in Fuzziness and Soft Computing, 242)

Computers & Technology

Yaochu Jin

Computer Science

Springer

Fuzzy rule systems have found a wide range of applications in many fields of science and technology. Traditionally, fuzzy rules are generated from human expert knowledge or human heuristics for relatively simple systems. In the last few years, data-driven fuzzy rule generation has been very active. Compared to heuristic fuzzy rules, fuzzy rules generated from data are able to extract more profound knowledge for more complex systems. This book presents a number of approaches to the generation of fuzzy rules from data, ranging from the direct fuzzy inference based to neural net works and evolutionary algorithms based fuzzy rule generation. Besides the approximation accuracy, special attention has been paid to the interpretabil ity of the extracted fuzzy rules. In other words, the fuzzy rules generated from data are supposed to be as comprehensible to human beings as those generated from human heuristics. To this end, many aspects of interpretabil ity of fuzzy systems have been discussed, which must be taken into account in the data-driven fuzzy rule generation. In this way, fuzzy rules generated from data are intelligible to human users and therefore, knowledge about unknown systems can be extracted.

Advanced Fuzzy Systems Design and Applications

Reference

Physica

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