The study of cortical oscillations is of great interest to those working in many areas of neuroscience. A fast coherent EEG rhythm called gamma or "40 Hz" has been implicated in cognition, as it may play a role in binding together features of objects. This rhythm may also be important for consciousness, as a number of drugs that induce general anesthesia disrupt the synchronization of the rhythm at clinically relevant concentrations. There is also suggestive evidence implicating dysfunction of gamma rhythms in Alzheimer's disease, and perhaps in other neuropsychiatric disorders.
In Fast Oscillations in Cortical Circuits, the authors use a combination of electrophysiological and computer modeling techniques to analyze how large networks of neurons can produce both epileptic seizures and functionally relevant synchronized oscillations. Specific topics covered include single hippocampal pyramid cells, hippocampal interneurons, synaptic interactions, gamma oscillations in brain slices as well as in vivo, the mechanisms of oscillation-synchronization (both local and long-range), the switch from gamma to beta frequencies and its implications for memory, and the significance of gamma oscillations for brain function.

Fast Oscillations in Cortical Circuits (Computational Neuroscience)

Science & Math

Traub, Roger D.

Whittington, Miles A.

Jefferys, John G. R.

Biological Sciences

MIT Press (MA)

Neuronal Networks of the Hippocampus

The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important new techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbors. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks.

Miles, Richard

Cambridge University Press

The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important new techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbors. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks.

Computers & Technology

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Books by Traub, Roger D.