<p>This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.</p>

p53 Suppressor Gene (Molecular Biology Intelligence Unit)

Tapas Mukhopadhyay Steven A. Maxwell Jack A. Roth

Health, Fitness & Dieting

Springer

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Books by Tapas Mukhopadhyay Steven A. Maxwell Jack A. Roth

See the best price to sell, buy, or rent books by Tapas Mukhopadhyay Steven A. Maxwell Jack A. Roth. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

p53 Suppressor Gene (Molecular Biology Intelligence Unit)