The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.

The Organic Chemistry of Drug Design and Drug Action

Science & Math

Silverman Ph.D Organic Chemistry, Richard B.

Holladay, Mark W.

Chemistry

Academic Press

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! * Emphasizes the use of the principles of physical organic chemistry as a basis for drug design * Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes * Uses figures and literature references extensively throughout * This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

Biological Sciences

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction.

This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides.   This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students.  Accessible via Adobe6.                                       * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises* User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases

The Organic Chemistry of Drug Design and Drug Action, Power PDF

Written for advanced undergraduate and graduate students as well as professionals in organic and medicinal chemistry and biochemistry, this unique text illuminates the "black box" of enzyme-catalyzed reactions by showing how enzymes are simply highly efficient organic chemists. Enzyme-catalyzed reactions are essential for the design of enzyme inhibitors in the pharmaceutical and agricultural industries, and of growing importance for process development in the chemical and biotechnology industries. Following a general introduction to the role of enzymes as catalysts, each chapter describes the organic reaction mechanisms that are used by enzymes to catalyze a particular family of organic transformations. The compilation includes a vast number of drawings to illustrate structures and mechanisms, and focuses on one or two examples of enzymes that catalyze the particular chemistry for that transformation. The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather the general mechanisms used by enzymes. Extensive references refer to the many experiments that have helped to elucidate enzyme mechanisms. Chemical model studies as an aid in mechanistic studies are also discussed, as are the design of haptens and the generation of catalytic antibodies ("designer enzymes"). Problem sets and solutions are provided to check the reader's understanding of the principles described. * Shows how enzyme-catalyzed reactions are simply efficient organic reaction * Emphasizes the connection between organic reaction mechanisms and enzyme mechanisms * Explains how enzymes can accelerate the rates of chemical reactions with high specificity * Uses selected enzymes to demonstrate general mechanisms of enzyme-catalyzed reaction * Illustrated with a vast array of clearly drawn structures, schemes, and figures * Includes an extensive bibliography on enzyme mechanisms * Describes approaches to the design of enzyme inhibitors * Covers catalytic antibody design and mechanisms * Provides problem sets and solutions for each chapter * Written in an informal and engaging style

The Organic Chemistry of Enzyme-Catalyzed Reactions

See the best price to sell, buy, or rent books by Silverman Ph.D Organic Chemistry, Richard B.. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Silverman Ph.D Organic Chemistry, Richard B.

See the best price to sell, buy, or rent books by Silverman Ph.D Organic Chemistry, Richard B.. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action, Power PDF

The Organic Chemistry of Enzyme-Catalyzed Reactions