Dna Fingerprinting: STATE OF THE SCIENCE (EXPERIENTIA SUPPLEMENTUM (EXS))

DNA fingerprinting had a well-defined birthday. In the March 7, 1985 issue of Nature, Alec Jeffreys and coworkers described the first develop­ ment ofmu1tilocus probes capable of simultaneously revealing hypervari­ ability at many loci in the human genome and called the procedure DNA fingerprinting. It was a royal birth in the best British tradition. In a few months the emerging technique had permitted the denouement of hith­ erto insoluble immigration and paternity disputes and was already heralded as a major revolution in forensic sciences. In the next year (October, 1986) DNA fingerprinting made a dramatic entree in criminal investigations with the Enderby murder case, whose story eventually was turned into a best-selling book ("The Blooding" by Joseph Wambaugh). Today DNA typing systems are routinely used in public and commercial forensic laboratories in at least 25 different countries and have replaced conventional protein markers as the methods of choice for solving paternity disputes and criminal cases. Moreover, DNA fingerprinting has emerged as a new domain of intense scientific activity, with myriad applications in just about every imaginable territory of life sciences. The Second International Conference on DNA Fingerprinting, which was held in Belo Horizonte, Brazil in November of 1992, was a clear proof of this.

DNA Fingerprinting: State of the Science (Exs, No 67)

S.D.J. Pena

R. Chakraborty

Jörg T. Epplen

S.D.J. Penna

Birkhauser

The objective of this book is to equip forensic scientists, biologists, ecologists, geneticists, biochemists and molecular biologists with up-to-date, authoritative information on, and research perspectives in the field of, polymorphic DNA tandem repeat polymorphisms (DNA fingerprinting). All aspects of the field are covered. Beginning with an authoritative general introduction to DNA fingerprinting, the book reviews basic knowledge, including the nature, genomic arrangements and variability of tandem repeated sequences. The first selection also addresses new approaches to the study of genomic variability, including PCR with random primers and the new technique of capillary electrophoresis. The second section deals with the application of DNA fingerprinting to concrete problems in our society. It starts with a presentation of the new revolutionary technique of MVRPCR and a review of transcribed polymorphic microsatellites and their role in the etiology of important human diseases. This is followed by an extensive discussion of the controversial issue of the population genetics of tandem repeat polymorphisms and the utilization of DNA fingerprinting in paternity testing and criminal analysis. The third part includes applications in the study of topics as varied as taxonomy, genetic improvement and population ecology in micro-organisms, plants, and animals, ranging from protozoa to primates. The authors are the foremost experts in the DNA fingerprinting field. By virtue of its scope and depth, this book answers a long-standing need for an authoritative text in DNA fingerprinting.

DNA Fingerprinting II (Experientia Supplementum)

Science & Math

Biological Sciences

Springer

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