This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.

Mouse Development: Patterning, Morphogenesis, and Organogenesis

Science & Math

Tam, Patrick T.

Rossant, Janet

Biological Sciences

Academic Press

The Harvey Society was founded in 1905 by thirteen New York City scientists and physicians with the purpose of forging a "closer relationship between the purely practical side of medicine and the results of laboratory investigation." The Society disseminates scientific knowledge in selected areas of anatomy, physiology, pathology, bacteriology, pharmacology, and physiological and pathological chemistry through public lectures, which are published annually. Topics covered in this series edition include sensing and signaling DNA damage; mammalian stem cells; nature, nurture, and genetic scripts; P53, mdm2, and cancer; viral membrane fusion and its inhibition; and genomics approaches to photoreceptor development and disease.

The Harvey Lectures: Series 97, 2001-2002

Harvey Society

Brown, Patrick O.

Cepko, Constance L.

Elledge, Stephen J.

Hudspeth, A. J.

Kim, Peter S.

Oren, Moshe

Zou, Lee

Wiley-Liss

During the last decade, research in developmental biology has undergone a dramatic change brought about by the availability of whole genome sequences from diverse organisms, the availability of transcriptomes and epigenomes, advanced imaging techniques and the increased understanding of the role of stem cells in organ and tissue development and regeneration. These advances have been integrated with traditional approaches of genetic manipulations and detailed phenotypic analyses in experimental model organisms such as the mouse. This book provides a contemporary overview of the conceptual framework of molecular and cellular mechanisms of mammalian development, and a glimpse into future directions in mammalian developmental biology and its relevance to cellular and tissue therapy. Major areas of focus are transcriptional and epigenetic switches and the activity of genetic networks in cell differentiation, the role of signaling pathways, and tissue modeling and organ formation. Another major focus is on the translation of basic knowledge of developmental processes into stem cell biology, directed differentiation of pluripotent or lineage-biased progenitors, and the potential for regenerative medicine. This book is aimed at senior undergraduates interested in the scope of modern developmental biology, graduate students and post-doctoral fellows who are beginning to explore the mouse as a model system for studying vertebrate development and its relevance to human diseases, and established scientists in fields outside the traditional areas of developmental biology who are looking to apply their knowledge and expertise in new ways.

Mammalian Development: Networks, Switches, and Morphogenetic Processes

Tam, Patrick P.L.

Nelson, W. James

Cold Spring Harbor Laboratory Press

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