China, India and Alternative Asian Modernities

Raj Kumar

Satya P. Mohanty

SANJAY KUMAR

Archana Kumar

Routledge India

The Business of Changing the World: How Billionaires, Tech Disrupters, and Social Entrepreneurs Are Transforming the Global Aid Industry

Beacon Press

<p>This book aims to assist the scientists working with the medicinal, biochemical, biophysical, genetic and pharmacological aspects of topoisomerases and their inhibitors. The book has covered various aspects of topoisomerases like classification, structural aspects, basic genetics and mutations, disease implications and cell signaling networks, which may be helpful for researchers of the field for better therapeutics. Chapter One deals with structure, functions and role and of human topoisomerase-I in cancer progression. It describes a detailed classification, mechanism of action and recent updates on the development of camptothecin and non-camptothecin derivatives, along with their Structure-Activity Relationships (SAR) as topoisomerase-I inhibitors. Chapters Two and Three cover X-ray co-crystal structures, biological functions and the significant role of topoisomerase-II isoforms in cancer. A thorough discussion on classification and various pharmacoinformatics techniques employed in delineating the binding mode of topoisomerase-II inhibitors and their mechanism of action is well presented. Chapter Four deals not only with adverse effects associated with the use of topoisomerase-I and II inhibitors, but also includes approaches to overcome them. Chapter Five discusses various disorders associated with SNPs in topoisomerases and risks associated with their pharmacogenetics. Chapter Six sheds light on interactions and cross-talks between topoisomerases and histone deacetylases, leading to their significant role in drug resistance. The work is expected to assist the scientists to selectively design dual/multi-inhibitors of topoisomerases and histone deacetylases. The authors are thankful to the reviewers, who were so kind in reviewing and making suggestions for improving this book. This book could not have been completed without their commendable efforts.</p>

Topoisomerase Inhibitors: Classification, Mechanisms of Action and Adverse Effects

Medical Books

Pharmacology

Nova Science Publishers, Inc.

Vargas

Sagar Publications

Charisma of Trika Houses

Health, Fitness & Dieting

Astro Remedies : A Vedic Approadh

Charisma of Upchaya House

Delineating a Horoscope

Charisma of Planets: Timing Events

<p>Medical astrology is a specialized branch of Vedic astrology. It is an extraordinary predictive and counseling tool. A horoscope indicates good, bad or indifferent traits and physical, emotional or spiritual characteristics of the native as per the Karmic flow. A chart is only the representation of one's Karmic implications in one's life through planetary influences. The medical astrology helps in understanding well in advance where the human chain is the weakest in the physical body and why. An astute astrologer will be able to diagnose disease and the diseased body part merely by analysis of the horoscope. He should be able to tell the susceptibility or the resistance which a native has for a particular disease. He may be able to tell the period of onset/ recovery from the disease and can also suggest the remedial measures to reduce its severity without any side effect. Once this is known, it will be easier for medicos to quickly arrive at the cause and place of diseased body part and the treatment to which the patient will respond.The diseases are generally indicated by the malefic influences of planets. Houses, signs and Nakshtras wherein the planets are placed indicate tendencies, susceptibility, resistance and potential of various ailments in the body. When these potential will manifest depends upon the dasha periods and transit of planets. The numbers of diseases which a native may have to encounter are numerous. However this book touches upon 112 diseases with the help of 102 illustrative charts. The last (16th) chapter of this book is devoted to common astrological remedies with a new Karmic and practical point of view to propitiate evil planets causing ailments.</p>

Medical Astrology

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Books by Raj Kumar