An extension of the 1986 edition to include higher organisms, focusing on how an organism uses its genes to direct its growth. New chapters assess how well the lambda model can explain gene control in eukaryotes, and the elaborations necessary to explain more complex systems. Annotation copyright Book News, Inc. Portland, Or.

Genetic Switch: Phage Lambda and Higher Organisms

Science & Math

Ptashne, Mark

Biological Sciences

Blackwell Science Inc.

"A Genetic Switch" is an introduction to gene function - specifically the genetic repressor. Understanding the repressor function is essential to an understanding of biochemical activity within the gene as it is fundamental to the process by which growth and development are regulated at the molecular level. The book is intended as a basic introduction to repressor function for both advanced and undergraduate and graduate level courses in genetics and biochemistry. It will also be essential reading for researchers and students of phage, viral and general genetics.

A Genetic Switch: Gene Control and Phage Lambda

Cell Press & Blackwell Scientific Publications

Genes & Signals

Genes &amp; Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.

Gann, Alexander

Cold Spring Harbor Laboratory Pr

The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long-range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.

A Genetic Switch, Third Edition: Phage Lambda Revisited

Cold Spring Harbor Laboratory Press

See the best price to sell, buy, or rent books by Ptashne, Mark. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Ptashne, Mark

See the best price to sell, buy, or rent books by Ptashne, Mark. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Genetic Switch: Phage Lambda and Higher Organisms

A Genetic Switch: Gene Control and Phage Lambda

Genes & Signals

Genes & Signals

A Genetic Switch, Third Edition: Phage Lambda Revisited