Molecular Mechanisms Influencing Aggressive Behaviours

Novartis Foundation

John Wiley&Sons

Novartis Foundation Symposium 289

Derek J. Chadwick

Jamie A. Goode

Wiley & Sons, Limited, John

Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain. This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans. Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed. The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions.

Neuronal and Cognitive Effects of Oestrogens No. 230

Science & Math

Symposium, Novartis Foundation

Biological Sciences

wiley

The field of neural transplantation is at a crucial stage in its development, with results of important clinical trials on transplantation in patients with Parkinson's disease expected soon and novel, alternative approaches to fetal transplantation being actively investigated. This timely book brings together leading neuroscientists, clinicians, and cell and developmenta; biologists to discuss the use of neural transplants in neurodegenerative diseases such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, such as xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book draws together much new and exciting work in this field, and identifies promising new research directions.

Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions No. 231

Health, Fitness & Dieting

Diseases & Physical Ailments

Evolutionary psychology and behavioural genetics are two successful and important fields in the study of human behaviour, but practitioners in these subjects have different conceptions of the nature of human intelligence. Evolutionary psychologists dispute the existence of general intelligence and emphasise the differences among species. They argue that natural and sexual selection would be expected to produce intelligences that are specialised for particular domains, as encountered by particular species. Behavioural geneticists consider general intelligence to be the most fundamental aspect of intelligence and concentrate on the differences between individuals of the same species. This exciting book features papers and discussion contributions from leading behavioural geneticists, evolutionary psychologists and experts on intelligence that explore the differences and the tensions between these two approaches. The nature of 'g' or general intelligence is discussed in detail, as is the issue of the heritability of intelligence. The alternative approaches that emphasise domain-specific intelligences are explored, alongside wide-ranging discussions on a broad range of issues such as the biological basis for intelligence, animal models and changes in IQ scores over time.

The Nature of Intelligence (Novartis Foundation Symposium, 233)

Mental Health

This important and exciting work brings together a high-calibre group of experts to discuss the practical application of genomic information to the development of drugs. Recent technological advances have led to a rapid acceleration in our ability to gather genetic data. The complete genetic sequences are now known for several organisms and accelerated programmes are in place for sequencing many other genomes, including human. The speed with which complete sequencing can be accomplished will continue to increase as new technologies come online. In principle, the scope for developing new diagnostic techniques and drugs is now greater than at any time in human history, but the pathway from genetic information to usable drug is a long and complex one. This major book covers such subjects as the current state of the art in squencing technology, the applications of these new technologies to sequencing the genomes of various organisms, and the challenge of proteomics. Additional contributions deal with legal and ethical implications of the new uses of genetic data, and functional genomics from the point of view of the pharmaceutical industry.

From Genome to Therapy: Integrating New Technologies with Drug Development - No. 229

Venter, J. Craig

Both timely and topical, this book examines the most important aspects of the relationship between alcohol consumption and health. Drawing together much new and exciting work in this area, it reviews this emotive subject from a dispassionate perspective. It will provide a firm base for further research into the effects of alcohol on the cardiovascular system, and into public health attitudes to what is both a universal pleasure and problem.

Alcohol and Cardiovascular Disease - Symposium No. 216

A comprehensive volume examining the fundamental questions raised by reductionists' theory about levels of explanation necessary to understand biological systems. The book evaluates the enormously powerful techniques of molecular biology, and analyzes precisely how molecular information has improved our understanding of fundamental biological processes.

The Limits of Reductionism in Biology - No. 213

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.

Epigenetics - No. 214

This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.

Immunological Tolerance - Symposium No. 215

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