Successful drug use in biology and medicine is often prejudiced by the failure of drugs that are otherwise active in vitro to act as efficiently in vivo. This is because in the living animal drugs must, as a rule, bypass or traverse organs, membranes, cells and molecules that stand between the site of administration and the site of action. In practice, however, drugs can be toxic to normal tissues, have limited or no access to the target and be prematurely excreted or inactivated. There is now growing optimism that such problems may be resolved by the use of carrier systems that will not only protect the non-target environment from the drugs they carry but also deliver them to where they are needed or facilitate their release there. Carrier systems presently under investigation include antibodies, glycoproteins, cells, reconstituted viruses and liposomes. Recent advances in the chemistry of cell receptor and receptor-recognising molecules, llnmunology, and natural and artificial membranes have revealed a multitude of ways in which such carrier systems can be modified or improved upon.

Targeting of Drugs (Nato Science Series A:)

JUDITH

North Atlantic Treaty Organization

SENIOR

Trouet Andre Gregoriadis, Gregory

Health, Fitness & Dieting

Plenum Press

These two volumes contain the papers presented at a North Atlantic Treaty Organization (NATO) Advanced Study Institute held on September 22-28, 1979 in Monte Carlo, Monaco. The conference was entitled "In Vitro Toxicity Testing of Environmental Agents: Current and Future Possibilities." This international conference presented an opportunity for the participants to exchange informa tion and ideas on the current approaches (both scientific and po litical) for toxic assessment of environmental agents. The poten tial health effects of these compounds as well as future needs in the environmental research field were discussed. The scientific content of the conference seminars included an overview of the various cellular, subcellular, organ, animal, and genetic systems which have been used to assess the health effects of environmental agents. The scientific principles behind short term assays and an evaluation of their applicability to health effects monitoring and analysis were investigated. Included among major topics were: (1) the biochemistry and pharmacology of selected environmental agents; (2) molecular mechanisms of car cinogenesis, mutagenesis, and transformation; (3) bacterial muta genesis and toxicity; (4) mammalian cell mutagenesis, toxicity, and transformation; (5) in vitro carcinogens and mutagens; (6) teratogenic and other developmental toxic effects; and (7) the development of short-term neuro-behavioral toxicity assays.

In Vitro Toxicity Testing of Environmental Agents: Current and Future Possibilities Part A: Survey of Test Systems (Nato Conference Series, 5)

Science & Math

Kolber, Alan R.

NATO Advanced Research Institute on in Vitro Toxicity Testing of Envi

Physics

Springer

<p>'MRI in Clinical Practice' provides an easily accessible source of reference material to supplement existing texts, distilling a wide breadth of theoretical and practical information into a pocket-sized manual. The book covers the basic Physics behind MRI, quality assurance, up-to-date safety guidelines and a useful gallery of image artefacts. Part of the book focuses on the specific areas of the body in which MRI is currently exploited, describing how MRI is performed in practice. As well as covering routine clinical techniques, the latest advanced methods (e.g. spectroscopy, fMRI, diffusion, high field MRI) are discussed and placed into the context of clinical application. Written from both a Physics and Radiological point-of-view, the book has a wide multidisciplinary appeal and is specifically targeted at MRI practitioners or trainees, as well as post-graduate students, physicists, radiographers and radiologists.</p>

In Vitro Toxicity Testing Of Environmental Agents, Current and Future Possibilities, Part B: Development of Risk Assessment Guidelines (NATO ... Ecology, Vol. 5b) (Nato Conference Series, 5)

Thomas J Hughes

Alan R. Kolber

Thomas K. Wong

Lester D. Grant

Algorithms provide the basic foundation for all computational processes.    This volume presents algorithms at the foundational level and also at the   various levels between this level and the user application. Some of         these algorithms are classical and have become well established in the  field. This material is therefore a rich source of information and is still relevant and up to date. The basic primitives of computer graphics have     remained unchanged: lines, circles, conics, curves and characters. This     volume contains reference material in all these areas. The higher levelsof contouring and surface drawing are also well covered. Developments in    hardware architectures have continued since the first printing, but the     basic principles of hardware/software trade-offs remain valid. This         reprint is being published as a Study Edition to make the material more accessible to students and researchers in the field of computer graphics andits applications. The continuing popularity of the original book            demonstrates the value and timeliness of its contents.

Fundamental algorithms for computer graphics (NATO ASI series. Series F, Computer and system sciences)

Earnshaw, Rae A.

Cambridge Interactive System

Mathematics

Springer, Verlag

<p>This book addresses the important and rapidly growing interface between the disciplines of computer science and control engineering. In particular, it provides a timely presentation by a group of recognized experts from several areas of control engineering of the state of the art in the application of advanced concepts and techniques from three fast developing areas of computer science: expert systems and artificial intelligence; algorithms for advanced parallel computer architectures; and discrete-event and distributed systems. Being based on a set of lectures given at a NATO Advanced Study Institute in the summer of 1987, the papers are of a tutorial nature and offer an important and unique opportunity to access material which has previously only appeared in a number of isolated journal or conference papers. In fact, in this tutorial form, some of the topics presented appear for the first time, notably in the burgeoning new field of discrete-event control. The book provides both an overview of the concepts and techniques and significant examples of their potential application to problems in both the design and implementation of control systems. Together with the large number of references provided with each paper, it offers an informed and comprehensive introduction and entry point into a rapidly developing new research area which has vital implications for the future of control engineering.</p>

Biomedical EPR - Part B: Methodology, Instrumentation, and Dynamics (NATO Asi Series: Series F: Computer & Systems Sciences)

Denham, Michael J.

Alan J. Laub (editors)

AMS-NASA-NATO Summer Seminar on Algebraic and Geometric Methods in Linear Systems Theory (1979 : Harvard University)

Algebraic and Geometric Methods in Linear Systems Theory: 018 (Lectures in Applied Mathematics, V. 18)

American Mathematical Society

Byrnes, Christopher I.

Martin, Clyde

United States National Aeronautics and Space Administration

Amer Mathematical Society

Advanced Science and Technology for Biological Decontamination of Sites Affected by Chemical and Radiological Nuclear Agents (NATO Science)

NATO Glossary of terms and definitions (English and French). Listing terms of military significance and their definitions for use in NATO.

NATO Glossary of Terms and Definitions

Reference

Words, Language & Grammar

CreateSpace Independent Publishing Platform

Nato, The Warsaw Pact, And The Iron Curtain

Richardson, Erik

Richardson, Erik, Author

Cavendish Square Publishing

Glossary of Terms and Definitions Concerning the Safety and Suitability for Service of Munitions, Explosives and Related Products

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