Ultimate Game

When three high-school-age video game fanatics purchase a new virtual reality game they have no idea they are about to be transported to the battlefields of Verdun, Guernica, and Bosnia

Mystery, Thriller & Suspense

Lehmann, Christian

Thrillers & Suspense

David R. Godine, Publisher

A chilling novel of suspense, virtual reality, and cyberterror by a major new author of young adult fiction. The story begins when Eric, Charles, and Andreas come upon the video store of their dreams, featuring a vast array of war games they've never even heard of (and they've heard of, and mastered, all of them). But there, amid the stacks of lurid boxes and scenes of cyber-carnage, is the most remarkable game of all, one pressed on them by the store's elderly proprietor, a clever sample of computer warfare called "The Ultimate Experience." Contained in a single diskette, without even a label, the unassuming game surpasses their wildest fantasies: the graphics are better than a movie, the simulated battlefields are historically and geologically perfect, and the action seems to put you right inside the screen. The feeling of "reality" is uncanny. But soon the three friends realize that the Game has a will of its own, and that far from being a dream, it has drawn each of them into his own personal nightmare one that they enter and exit without any control. For Charles, it means suddenly finding himself at the head of a doomed French battalion in the darkest days of World War I, forced to choose which men to send to their deaths. Eric, meanwhile, is a resistance fighter in Guernica during the Spanish Civil War, on the very day in 1937 that German bombers reduced the town and its people to ashes. And Andreas, the oldest and most troubled and most vicious of the three, must face up to his own demons, discovering that, far from being terrified of the carnage around him, he revels in it. Little by little, the Game takes over their lives, leaving Eric, Charles, and their loved ones at its mercy while an increasingly violent Andreas plunges ever deeper into its seductive and deadly power. As the final showdown looms on the stage of virtual history, the three boys are inexorably drawn toward a memorable and horrifying conclusion. Christian Lehmann has fashioned a spellbinding adventure in cyberspace, a tour de force of contemporary technology and historical recreation. His narrative bravely explores a subject that is new and without parallel, investigating not only the powers of games and computers in modern society, but also the lessons that history has taught us. It is a story that will stay with you long after the last page has been turned.

Literature & Fiction

Literary

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

The Endocannabinoid System in Local and Systemic Inflammation (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease)

Health, Fitness & Dieting

Kelly, Melanie E. M.

Zhou, Juan

Diseases & Physical Ailments

Morgan Claypool

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies. Chapter 1 focuses on the immunologic staging of sepsis-the key for successful treatment of the dysregulated hot response. Chapter 2 reveals similarities in the immune response in sepsis and cancer-opening new avenues for novel therapies. Chapter 3 introduces an important modulator of the immune response-the endogenous cannabinoid system and elucidates its role in organ dysfunction in sepsis. Facing the increasing bacterial resistance to classical antibiotics, Chapter 4 discusses two unique mechanisms to treat infection and inflammation in sepsis: iron chelation, and the sphingosine pathway. The authors, all experts in experimental and clinical sepsis research, seek to provide further understanding of the complexities of the immune response as the physiological basis for the development of new therapeutics in sepsis.

Sepsis: Staging and Potential Future Therapies (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease)

Caldwell, Charles C.

Alternative Medicine

Endocannabinoid System in Local and Systemic Inflammation (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease)

No pasarán, le jeu

Teen & Young Adult

La Folie Kennaway

Genre Fiction

Rivages *

Patients, si vous saviez...: Confessions d'un médecin généraliste

POINTS

Tenir la ligne: Chronique d'une pandémie

OLIVIER

Thoughts on Grammaticalization (Lincom Studies in Theoretical Linguistics)

Reference

Foreign Language Study & Reference

Lincom Europa

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