Tuberculosis (TB) is a serious infectious disease of the lungs that is usually caused by the bacterium Mycobacterium tuberculosis. Nearly one-third of the world's population is currently infected with latent TB, and millions of individuals develop the active, potentially fatal form of the disease each year. The continuing emergence and spread of drug-resistant TB strains is one of the most difficult challenges facing control of the disease. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of M. tuberculosis biology, transmission, and infection, as well as ongoing strategies to treat and control it. Contributors explore the biological characteristics of M. tuberculosis, its complex interactions with the human immune system, and factors that influence the progression from latent to active TB disease (e.g., coinfection with HIV/AIDS). The clinical manifestations of TB, both pulmonary and extrapulmonary, are fully described and illustrated. This volume also includes discussions of recent advances in the development of diagnostics, drugs, and vaccines, as well as strategies for enhanced implementation of existing interventions. It is an essential reference for microbiologists, immunologists, pathologists, epidemiologists, and clinicians, and all who wish to understand and combat this global health burden.

Tuberculosis (Subject Collection from Cold Spring Harbor Perspectives in Medicine)

Science & Math

Kaufmann, Stefan H. E.

Rubin, Eric

Zumla, Ali

Biological Sciences

Cold Spring Harbor Laboratory Press

Impfen: Grundlagen, Wirkung, Risiken

Medical Books

History

Beck C. H.

It has been said that the development of vaccines against a variety of infectious diseases is among the greatest triumphs of immunology. Indeed, several pathogens have lost their horror through the availability of effective vaccination measures. Unfortunately, this does not hold true for the pathogens dealt within this volume. Malaria, schistosomiasis, leishmaniasis, leprosy, and tuberculosis together are prevalent in more than 100 countries, and over 400 million persons suffer from these diseases. It is becoming increasingly clear that the failure to control these infections in a satisfactory way is directly related to the complexity oftheir interactions with the immune system. These agents have lived with their hosts for long enough to give both-host and parasite-ample opportunity to develop a highly sophisticated interrelationship. The central role of T lymphocytes both in acquired resistance to and pathogenesis of these microbes is well appreciated. In the beginning it may have been thought that acq uired resistance against infectious agents is nothing but another aspect of the immune response, studied with soluble and particulate antigens. This simple concept has gradually changed, and it has become clear that the viability not only of the immune cells but also of the 'antigens' adds another dimension to the game. Several achievements in cellular immunology and molecular biology have now made it possible to better understand at least some mechanisms in this intricate interplay.

T-Cell Paradigms in Parasitic and Bacterial Infections (Current Topics in Microbiology and Immunology)

Health, Fitness & Dieting

Diseases & Physical Ailments

Springer

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