Being that pharmacokinetics (PK) is the study of how the body handles various substances, it is not surprising that PK plays an important role in the early development of new drugs. However, the clinical research community widely believes that mathematics in some way blurs the true meaning of PK. Demonstrating that quite the opposite is true, Computational Pharmacokinetics outlines the fundamental concepts and models of PK from a mathematical perspective based on clinically relevant parameters.\nAfter an introductory chapter, the book presents a noncompartmental approach to PK and discusses the numerical analysis of PK data, including a description of an absorption process through numerical deconvolution. The author then builds a simple physiological model to better understand PK volumes and compares this model to other methods. The book also introduces compartmental models, discusses their limitations, and creates a general-purpose type of model. The final chapter looks at the relationship between drug concentration and effect, known as PK/pharmacodynamics (PD) modeling.\nWith both a solid discussion of theory and the use of practical examples, this book will enable readers to thoroughly grasp the computational factors of PK modeling.

Computational Pharmacokinetics

Science & Math

Källén, Anders

Mathematics

Chapman and Hall/CRC

Understanding Biostatistics looks at the fundamentals of biostatistics, using elementary statistics to explore the nature of statistical tests. This book is intended to complement first-year statistics and biostatistics textbooks. The main focus here is on ideas, rather than on methodological details. Basic concepts are illustrated with representations from history, followed by technical discussions on what different statistical methods really mean. Graphics are used extensively throughout the book in order to introduce mathematical formulae in an accessible way. Key features: <ul>
<li>Discusses confidence intervals and p-values in terms of confidence functions. </li> <li>Explains basic statistical methodology represented in terms of graphics rather than mathematical formulae, whilst highlighting the mathematical basis of biostatistics. </li> <li>Looks at problems of estimating parameters in statistical models and looks at the similarities between different models. </li> <li>Provides an extensive discussion on the position of statistics within the medical scientific process. </li> <li>Discusses distribution functions, including the Guassian distribution and its importance in biostatistics. </li> </ul>
This book will be useful for biostatisticians with little mathematical background as well as those who want to understand the connections in biostatistics and mathematical issues.

Understanding Biostatistics

Biological Sciences

wiley

Being that pharmacokinetics (PK) is the study of how the body handles various substances, it is not surprising that PK plays an important role in the early development of new drugs. However, the clinical research community widely believes that mathematics in some way blurs the true meaning of PK. Demonstrating that quite the opposite is true, Computational Pharmacokinetics outlines the fundamental concepts and models of PK from a mathematical perspective based on clinically relevant parameters. After an introductory chapter, the book presents a noncompartmental approach to PK and discusses the numerical analysis of PK data, including a description of an absorption process through numerical deconvolution. The author then builds a simple physiological model to better understand PK volumes and compares this model to other methods. The book also introduces compartmental models, discusses their limitations, and creates a general-purpose type of model. The final chapter looks at the relationship between drug concentration and effect, known as PK/pharmacodynamics (PD) modeling. With both a solid discussion of theory and the use of practical examples, this book will enable readers to thoroughly grasp the computational factors of PK modeling.

Computational Pharmacokinetics (Chapman & Hall/Crc Biostatistics Series, 23)

Denna bok är en nyutgåva av ett kompendium om analytiska funktioner i en komplex variabel som Lars Hörmander gav 1979.

Introduktion till analytiska funktioner: Föreläsningar av Lars Hörmander (Swedish Edition)

Hörmander, Lars

lulu.com

See the best price to sell, buy, or rent books by Källén, Anders. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Källén, Anders

See the best price to sell, buy, or rent books by Källén, Anders. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Computational Pharmacokinetics

Understanding Biostatistics

Computational Pharmacokinetics (Chapman & Hall/Crc Biostatistics Series, 23)

Introduktion till analytiska funktioner: Föreläsningar av Lars Hörmander (Swedish Edition)