Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.

Science & Math

Lacy, Charles F.

Howie, Alexander J.

Goldman, Morton P.

Lance, Leonard L.

FRIEDMAN, HERMAN

Weisman

Katz, Lynda J.

Goldstein, Gerald

Beers, Sue R.

Young, David B.

Honeyman, Allen

Lajtha, Able

Bendinelli, Mauro

Newland, Robert

Biological Sciences

Springer

This handbook provides a short, clear, useful and interesting guide to the findings in renal biopsy specimens. Essential information needed for an understanding of renal disorders is given simply and concisely. The focus is on common conditions. The book is intended to be of practical help primarily to pathologists and trainee pathologists who look at renal biopsy specimens, but also to others who have contact with anyone with renal disorders. The handbook includes more than 240 color illustrations. Other features include practical tips on the differentiation between possible diagnoses and information about eponyms.

Handbook of Renal Biopsy Pathology

Health, Fitness & Dieting

Medical Books

Medicine

This handbook provides a short, clear, useful and interesting guide to the findings in renal biopsy specimens. Essential information needed for an understanding of renal disorders is given simply and concisely. The focus is on common conditions. The book is intended to be of practical help primarily to pathologists and trainee pathologists who look at renal biopsy specimens, but also to others who have contact with anyone with renal disorders. The handbook includes more than 240 color illustrations. Other features include practical tips on the differentiation between possible diagnoses and information about eponyms.\nFrom the Back Cover\nThis updated new edition provides a concise and practical guide to the interpretation of renal biopsy specimens. Each chapter has been updated to cover recent advances, with current terminology and information about newly recognized conditions. The latest classification systems and their practical application are included. 
Handbook of Renal Biopsy Pathology, Third Edition shows readers how the diagnosis can be made from the clinical indication for the biopsy, and interpretation of changes in the specimen. The book is relevant to trainee and practicing pathologists and nephrologists, and to others with contact with people with renal disorders, such as transplant surgeons, dialysis and transplant nurses, pharmacists, and medical students.

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