Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes enhance physical performance, improve mental health, and delay the onset of aging and disease. Understanding the molecular basis of these changes is therefore important for optimizing athletic ability and for developing drugs that elicit therapeutic effects. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular function. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered. The authors also discuss how the understanding of such molecular mechanisms may lead to the development of drugs that mitigate aging and disease. This volume will therefore serve as a vital reference for all involved in the fields of sports science and medicine, as well as anyone seeking to understand the molecular mechanisms by which exercise promotes whole-body health.

The Biology of Exercise (Perspectives CSHL)

Science & Math

Hawley, John A

Joyner, Michael J.

Zierath, Juleen R.

Biological Sciences

Cold Spring Harbor Laboratory Press

"The key questions for today's managers and leaders," writes Jack Hawley, "are no longer issues of task and structure, but questions of spirit." Not only do we all yearn for spiritually rooted qualities at work, those very qualities-integrity, character, love, inspiration, faith, reverence-are key factors in an enterprise's success. Through real-life examples, Hawley shows how people can create improved workplaces and more resilient, effective, and successful organizations. He shows how leaders and managers who are motivated by a spiritual vision will liberate the best in people, and explains why all leadership is spiritual. Hawley offers examples of people actually living by their inner truth at work, and shows how such people can create an improved place to work and a more resilient, effective organization.

Reawakening the Spirit in Work: The Power of Dharmic Management

Business & Money

HAWLEY, JACK

Management & Leadership

Berrett-Koehler Publishers

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Books by Hawley, John A