<p>From reviews of previous volumes in the series: 'Extremely valuable...thoroughly recommended.'-Annals of Human Genetics 'The most lucid and stimulating discussions of the topic to be found anywhere.'-American Scientist</p>

Advances in Human Genetics

Harry Harris

Springer

From reviews of previous volumes in the series: 'Extremely valuable...thoroughly recommended.'-Annals of Human Genetics 'The most lucid and stimulating discussions of the topic to be found anywhere.'-American Scientist

Advances in Human Genetics 6

Science & Math

Evolution

<p>1 Chromosomal Abnormalities in Leukemia and Clinical and Biological Significance.- Methods.- Chronic Myelogenous Leukemia (CML).- Chronic Phase of CML.- Acute Phase of CML.- The Ph1 Chromosome As a Biological Marker.- Acute Nonlymphocytic Leukemia (ANLL) de Novo.- Chromosome Gain and Loss.- Structural Rearrangements.- Acute Nonlymphocytic Leukemia Induced by Treatment.- Acute Lymphocytic Leukemia (ALL).- The 8;14 Translocation.- 14q+.- The 4;11 Translocation.- Near-Haploid ALL.- Hyperdiploidy with 50-60 Chromosomes.- The Ph1 Chromosome in ALL.- Malignant Lymphoma (ML).- Burkitt Lymphoma.- Other Non-Hodgkin Lymphoma.- The Biological Significance of Consistent Chromosomal Abnormalities.- When Do Chromosomal Rearrangements Occur?.- Defining the Critical Recombinant Chromosome.- Chromosomal Localization of Cellular Oncogenes.- Specificity of Chromosomal Rearrangements.- References.- 2 An Algorithm for Comparing Two-Dimensional Electrophoretic Gels, with Particular Reference to the Study of Mutation.- The Theory and Practice of Two-Dimensional Gels, with Particular Reference to the Study of Mutation.- The General Problem of Image Comparison.- Thresholding Spot Intensity.- Adjusting for Positional Variations.- A Set of Algorithms for Detecting Potential Mutational Events.- Estimating the Locations of Protein Spots.- Defining Spot Neighborhoods.- Finding a Subset of Matching Spots.- Iteration of Matching Step.- Recovery from Mismatches.- What the Algorithm Does Not Do.- Validation of the Current Algorithm.- Algorithm Performance on Artificially Constructed Gels.- Algorithm Performance on Real Gels.- Algorithm Performance on Simulated Mutations.- Improving the Necessary Developments in the Algorithm.- A More Rigorous Treatment of the Noise Function.- Improving the Accuracy of the Algorithm.- Increasing the Speed of Execution.- of a Priori Knowledge.- Improving the Necessary Developments in Two-Dimensional Gels.- Experimental Validation of This Approach.- Some Issues in Data Management.- Summary.- Recent Developments.- References.- 3 The Human Argininosuccinate Synthetase Locus and Citrullinemia.- Historical Aspects.- Biology of the Argininosuccinate Synthetase Locus.- Biochemistry of the Enzyme.- Cloning of Human Argininosuccinate Synthetase Gene.- Argininosuccinate Synthetase Pseudogenes.- Citrullinemia-Clinical Aspects.- General Description.- Differential Diagnosis.- Therapy.- Prognosis.- Prenatal Diagnosis.- Molecular Analysis in Citrullinemia.- Molecular and Genetic Analysis of Regulation.- Gene Transfer Using the Argininosuccinate Synthetase Locus.- Future Directions.- References.- 4 Molecular Genetics of the Human Major Histocompatibility Complex.- Characterization of the HLA Genes.- Isolation of the HLA (Class I and II) Genes.- Multiplicity of Class I and Class II Genes.- Structure, Polymorphism, and Evolution of the HLA Genes.- HLA Genes As Probes.- Transcription.- Genetic Polymorphism and Disease Association.- Function.- Conclusion.- References.- 5 Genetics of Human Alcohol and Aldehyde Dehydrogenases.- Alcohol Dehydrogenases.- Definition.- Nomenclature of Human ADH Loci.- Tissue Distribution of ADH Isozymes.- Genetic Variation in ADH.- Population Frequencies of Class I ADH Allelic Variants.- Purification of Human ADH.- Kinetic Differences between ADH Isozymes.- Determinations of the Amino Acid Sequences of ADH Isozymes.- Studies on the Immunologic Properties of ADH Isozymes.- Molecular Genetic Studies on Alcohol Dehydrogenase.- Aldehyde Dehydrogenases.- Definition.- Nomenclature of Human Aldehyde Dehydrogenase (ALDH)Loci.- Tissue Distribution of ALDH Isozymes.- Allelic Variation in ALDH Isozymes.- Structure of ALDH Isozymes.- Properties of ALDH Isozymes.- Amino Acid Sequence Determinations of ALDH Polypeptides.- Formaldyhyde Dehydrogenase (FDH).- Molecular Studies on ALDH Genes.- Chromosomal Assignment of ALDH1 and ALDH2 Genes.- References.- Addendum.</p>

Advances in Human Genetics 15

Principles of Human Biochemical Genetics

Elsevier Science Ltd.

Elsevier

Under oars: Reminiscences of a Thames lighterman, 1894-1909

Centreprise Trust Ltd. : Stepney Books Publications

Springer London, Limited

In 2004, Chelsea's billionaire owner, Roman Abramovich, needed the best manager money could buy, a proven champion, to capture the trophies his outlay on the team demanded. His choice was, of course, the irrepressible Jose Mourinho. Bringing his monumental self-belief and proven track record - not to mention a touch of elan - to the Premiership, Mourinho smashed the stranglehold that Alex Ferguson and Arsene Wenger held over English football's top prizes. Uniting Abramovich's impressive transfer outlay with his meticulous preparation and motivational skills, Mourinho elevated Chelsea to heights their fans had previously only dreamt of, winning the Premiership and Carling Cup double. Having delivered Chelsea's first top-flight domestic title in 50 years, Mourinho was never likely to rest on his laurels. His recruitment of the finest players in world football continued over the following two seasons, with the likes of Ashley Cole and Michael Essien bolstering the ranks, and inevitable success came in the shape of back-to-back championships in the second season, and a potential cup double in his third. It hasn't all been smooth sailing for The Blues' self-appointed 'Special One'. Critics have cited Mourinho's clear advantages in the transfer market, but it is his phenomenal manmanagement skills that have turned Chelsea from also-rans into the team everyone wants to beat. The unconditional loyalty of his players - most notably John Terry and Frank Lampard - is proof of the Mourinho effect. His unabashed confidence and will to win has seen him clash with rival managers, referees and other players alike; and his position as manager has not always seemed secure. But one thing is sure of Jose Mourinho; confident, eloquent, dapper in his attire and debonair to the core, English football would be a far less interesting sport without him. "Jose Mourinho - Simply the Best" is a celebration of his three years with The Blues.

Jose Mourinho

Biographies & Memoirs

Blake Publishing

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Books by Harry Harris