<p>This book provides a comprehensive review of the field of peptide biosynthesis. Individual chapters range from historical perspectives of the field to current knowledge regarding specific enzymes. Every step from gene to final bioactive peptide is covered in detail. Approximately two thirds of the book reviews the enzymes responsible for intracellular and extracellular peptide processing. Other chapters cover issues such as tissue-specific processing and the subcellular sorting of the peptides. New areas covered include the discovery, purification, characterization, and cDNA cloning of peptide processing enzymes involved with endopeptidase processing, carboxypeptidase processing, and C-terminal amidation; identification of the mammalian KEX-2 (subtilisin-like) family of proteases; identification of a second enzyme involved in C-terminal amidation; and the characterization of regulatory elements in neuropeptide genes and the associated DNA-binding proteins, such as CREB and related proteins, in addition to the Pit-1/GHF-1 family of proteins. The book's extensive coverage and 1000 references make it important reading material for new and established researchers in this rapidly expanding field.</p>

Peptide Biosynthesis and Processing (Telford Press)

Science & Math

Fricker, Lloyd D.

Biological Sciences

CRC-Press

Neuropeptides and peptide hormones represent the largest class of chemical messengers that transmit information from one cell to another. In this review, several decades of research on peptides in cell-cell signaling are summarized, with a focus on neuropeptide discovery, biosynthesis, and function. In addition to covering the well-studied aspects of neuropeptides, emerging concepts are discussed, including classical versus non-classical neuropeptides and direct versus indirect neuropeptides. Other potential functions for peptides in intercellular and intracellular signaling are also discussed.  Table of Contents: Overview of Neuropeptides / Neuropeptide Discovery / Neuropeptide Biosynthesis / Neuropeptides After Secretion: Receptors and Peptidases / Representative Neuropeptides / Concluding Remarks and Future Directions / References / Author Biography

Neuropeptides and Other Bioactive Peptides: From Discovery to Function (Colloquium Series on Neuropeptides)

Morgan & Claypool Life Sciences

Neuropeptides: From Discovery to Function (Colloquium Series on Neuropeptides)

Medical Books

Basic Sciences

MORGAN AND CLAYPOOL

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