Drug design is intrinsically involved in the discovery of a new drug: it can be incorporated into the identification of a lead compound by intelligent screening; involved when a new molecule for synthesis is created by computer or by intuition, based upon an intelligent understanding of the protein target; or in converting compounds such as peptides and carbohydrates into peptidomimetics or carbohydramimetics, retaining the original role of the compound while operating pharmaceutically. The design element is involved in the application of knowledge of structure-activity relationships to predict activities of designed but yet unsynthesized compounds, and in the synthesis itself. This text updates the first Rhone-Poulenc Rorer Round Table Conference volume on the subject of drug design. It covers topics from the practicalities of synthetic organic chemistry to the potential pitfalls in the mathematics of free-energy calculations.

New Perspectives in Drug Design

Medical Books

Dean, M.

Jolles, G.

Pharmacology

Academic Pr

What was the role played by local police volunteers in the Holocaust? Using powerful eye-witness descriptions from the towns and villages of Belorussia and Ukraine, Martin Dean's book reveals local policemen as hands-on collaborators of the Nazis. They brutally drove Jewish neighbours from their homes and guarded them closely on the way to their deaths. Some distinguished themselves as ruthless murderers. Outnumbering German police manpower in these areas, the local police were the foot-soldiers of the Holocaust in the East.

Collaboration in the Holocaust: Crimes of the Local Police in Belorussia and Ukraine, 1941-44

Science & Math

PALGRAVE~MACMILLAN

Paperless Airplanes: Toys and Noise from the Blue

Literature & Fiction

Poetry

Little Boy Blue

<p>What was the role played by local police volunteers in the Holocaust? Using powerful eye-witness descriptions from the towns and villages of Belorussia and Ukraine, Martin Dean's new book reveals local policemen as hands-on collaborators of the Nazis. They brutally drove Jewish neighbors from their homes and guarded them closely on the way to their deaths. Some distinguished themselves as ruthless murders. Outnumbering German police manpower in these areas, the local police were the foot-soldiers of the Holocaust in the east.</p>

<p>This story is told in dual perspective by Miriam (a second-generation Iranian immigrant living in Edinburgh with her family) and George (a visitor from Wales). Their relationship throughout the decades mirrors the Beatles’s. In the other stories in this book, thematically bound by relationship flux and the impact of culture, Dean experiments beautifully with style and storytelling devices in each piece.</p>

I Am Young

Comics & Graphic Novels

Graphic Novels

Fantagraphics Books

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Books by Dean, M.