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The Sequence: Inside the Race for the Human Genome

Politics & Social Sciences

Davies, Kevin

Anthropology

Weidenfeld&Nicolson

The definitive insider's history of the genetic revolution--significantly updated to reflect the discoveries of the last decade. James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, agricultural chemistry, as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact--practical, social, and ethical--on our society and our world.

DNA: The Story of the Genetic Revolution

Science & Math

Berry, Andrew

Watson, James D.

Biological Sciences

KNOPF

September 1994. "The most impassioned and publicly visible of all genetic races" (The New York Times) comes to a triumphant close with the discovery of BRCA1, popularly known as the breast cancer gene. The result of a four-year international effort involving scientists from the United States, Canada, England, France, and Japan, among others, it is hailed as one of the most significant discoveries in recent medical science. 
Breakthrough is the brilliant account of this historic undertaking, its origins and development, and its implications for the future. With vivid profiles of the people and politics behind the events, Kevin Davies and Michael White unfold a scientific detective story that offers a rare glimpse into the complex—and fiercely competitive—world of genetic research. The race began in October 1990, when Dr. Mary-Claire King startled the American Society of Human Genetics with the news that after fifteen years, her research group had found irrefutable evidence of a gene linking heredity and the risk of breast cancer. From that moment on, the quest to isolate the gene became the focus of worldwide attention, eventually reaching fever pitch. In a race against time and one another, "researchers relentlessly zeroed in on a piece of DNA too small to see, for a prize too enormous to contemplate." In addition to the pioneering Dr. King, the distinguished scientists profiled include the renowned Francis Collins, who discovered the genes for cystic fibrosis and Huntington's disease, and Mark Skolnick, the entrepreneurial founder of Myriad Genetics, who made fascinating use of the genealogical records of Mormons in his quest for the gene. The intensity of the project brought out the extremes of scientific research, from exhilarating enthusiasm and cooperation to heated rivalry. Beyond its fast-paced chronicle of discovery, Breakthrough is also a story of the politics of illness, focusing on the impact of the women's movement on breast cancer research and the changing attitudes of the past twenty-five years. Although, as the authors state, our "heightened awareness of the disease has been very late in coming," there is genuine cause for hope. Looking to the future, they explore current methods of screening and treatment as well as the prospects for a cure. In the United States alone, 183,000 new cases of breast cancer are diagnosed each year—50,000 in women under the age of forty. Breakthrough is proof that modern medicine can at last offer something tangible in the battle against a unique disease about which shockingly little is known. Rare blend of science, medicine, politics, and human nature. Breakthrough is the intriguing real-life detective story behind one of the most important genetic research discoveries of recent times. "Breakthrough is an absorbing and authoritative account of that quest, with an admirable grasp of the roles of the different scientists."—New Scientist "Isolation of [the breast cancer gene] was an extraordinary technical tour de force, a major medical advance, and perhaps the last great all-out battle of the big gene-cloning empires. As an all-embracing account of the current state of breast cancer, this book has something for everyone."—Nature

Breakthrough: The Race to Find the Breast Cancer Gene

Health, Fitness & Dieting

WHITE,MICHAEL

Diseases & Physical Ailments

wiley

Royal Postgraduate Medical School, London, U.K. Exam review for the MRCP, for U.K. medical students. Includes 155 exam-style questions with rationales. Covers both clinical and basic sciences. Softcover.

Modern Medicine for the MRCP

Medical Books

Aitman, Timothy J.

Mason, Justin

Davies, Kevin A.

Nursing

W.B.SAUNDERS COMPANY

A story of the race to crack the secrets of the human genome captures all the drama of the players involved, the project's leaders, Francis Collins and Craig Venter, and the secrets behind the most important scientific achievement of our time.

Cracking The Genome: Inside The Race To Unlock Human Dna

Business & Money

Free Press

The Sequence : Inside the Race for the Human Genome

Phoenix (an Imprint of The Orion Publishing Group Ltd )

In 1953, James Watson and Francis Crick unveiled the double helix structure of DNA. The discovery was a profound moment in the history of science, but solving the structure of the genetic material did not reveal what the human genome sequence actually was, or what it says about who we are. Cracking the code of life would take another half a century. 
In 2001, two rival teams of scientists shared the acclaim for sequencing the human genome. Kevin Davies, founding editor of Nature Genetics, has relentlessly followed the story as it unfolded week by week since the dawn of the Human Genome Project in 1990. Here, in rich human and scientific detail, is the compelling story of one of the greatest scientific feats ever accomplished: the sequencing of the human genome.
In brilliant, accessible prose, Davies captures the drama of this momentous achievement, drawing on his own genetics expertise and on interviews with the key scientists. Davies details the fraught rivalry between the public consortium, chaperoned by Francis Collins, and Celera Genomics, directed by sequencer J. Craig Venter. And in this newly updated edition, Davies sheds light on the secrets of the sequence, highlighting the myriad ways in which genomics will impact human health for the generations to come.
Cracking the Genome is the definitive, balanced account of how the code that holds the answer to the origin of life, the evolution of humanity, and the future of medicine was finally broken.

Cracking the Genome: Inside the Race to Unlock Human DNA

Johns Hopkins University Press

It's 3am and I Can't Use the Buzzsaw: Anxiety, Mental Health and Me

Mental Health

Kevin Davies

Since the conclusion of the Human Genome Project in 2003, scientists have been racing toward a grand goal: offering individuals a decoding of their complete genetic makeup for just $1,000. As Kevin Davies reveals in this exquisitely reported account, the $1,000 genome will be a reality by 2011 and it will usher in a whole new era of personalized, genomic medicine. Capable of presenting much more advanced information than the current crop of cheek-swab services, the $1,000 complete genome raises some extraordinary possibilities. We will be able to learn if we have genes that predispose us to a host of diseases and to take a wide range of preventative measures. Drug companies may be able to create versions of drugs tailored specifically to our individual DNA. But we may also face the psychological burden of learning that we have the gene for an incurable disease, such as Parkinson's.     Acclaimed author Kevin Davies introduces the pioneers of this medical revolution and probes deeply into both the medical benefits and ethical issues of personal genetic testing, also exploring the psychological complexities of learning one's DNA results, based on both his own experience of being tested and that of a number of others. The $1,000 Genome is an indispensable guide to the new era of personalized medicine.

The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine

Tantor Audio

In 2000, President Bill Clinton signaled the completion of the Human Genome Project at a cost in excess of $2 billion. A decade later, the price for any of us to order our own personal genome sequence—a comprehensive map of the 3 billion letters in our DNA—is rapidly and inevitably dropping to just $1,000. Dozens of men and women—scientists, entrepreneurs, celebrities, and patients—have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer’s or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions—and many more—by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure. Indeed, many experts are advocating that all newborns have a complete genome analysis done so that preventive measures and preemptive medicine can begin early in life. How has this astonishing achievement been accomplished? And what will it mean for our lives? To research the story of this unfolding revolution, critically acclaimed science writer Kevin Davies has spent the past few years traveling to the leading centers and interviewing the entrepreneurs and pioneers in the race to achieve the $1,000 genome. He vividly brings to life the extraordinary drama of this grand scientific achievement, revealing the masterful ingenuity that has transformed the process of decoding DNA and delivering the information it possesses to the public at large. Davies also profiles the future of genomic medicine and thoughtfully explores the many pressing issues raised by the tidal wave of personal genetic information. Will your privacy be protected? Will you be pressured, by insurance companies or by your employer, to get your genome sequenced? What psychological toll might there be to discovering you are at risk for certain diseases like Alzheimer’s? And will the government or the medical establishment come between you and your genome? One thing that is not in question is that we are moving swiftly into the personalized medicine era, and The $1,000 Genome is an essential guide to this brave new future.

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Books by Davies, Kevin