In the exciting and rapidly expanding field of drug development, there is an emphasis on the clear delineation of psychiatric symptoms, syndromes and disorders, and disorders, and improved strategies for making diagnoses. Here the authors concentrate on the anxiolytics, a group of drugs which must be evaluated in carefully defined groups of patients using sensitive outcome measures. Efficacy is not always easy to establish and large clinical trials are needed to verify effectiveness of the drug, the degree of efficacy and the risks of unwanted effects. Conducting these trials is not an easy matter and this timely, critical and comprehensive guide aims to provide awareness of the major issues surrounding development of anxiolytics and, in particular, details of the techniques needed to assess new and hopefully improved therapies. This book, written by authors well known for their extensive experience in the field of drug development, will be of interest to the academic community frequently involved in clinical trials of potential anxiolytic compounds, as well as to the pharmaceutical industry in the formulation of drug development programmes for new anxiolytics.

Anxiolytic Compounds: Perspectives in Drug Development

Health, Fitness & Dieting

Cutler, Neal R.

Sramek, John J.

Kurtz, Neil M.

Psychology & Counseling

John Wiley & Son Ltd

The interest in developing novel antipsychotics is especially keen at this time and this book presents the latest information in that development. Numerous compounds are in the preclinical and clinical pipeline. The pharmaceutical industry, as well as psychiatrists, clinicians, mental health professionals and anyone else interested in the design and conduct of clinical trials of schizophrenia, are waiting for these research results. Revealing recommendations for developing antipsychotic compounds based on the extensive experience of the authors, this work will provide long-awaited information on a previously unexplored area.

Optimizing the Devlopment of Antipsychotic Drugs

Murphy, Michael F.

Carta, Angelico

Mental Health

wiley

Understanding Alzheimer's Disease (Understanding Health and Sickness Series)

Alzheimer's disease has received growing attention in recent years because the affected population is growing quickly as life spans in America creep ever upward. As they near retirement, many Americans start to fear that any minor memory lapse-misplacing the keys or forgetting a name-might spell Alzheimer's. In reality such incidents are a normal part of the aging process. In Alzheimer's disease, such incidents progress to a point at which they interfere with normal daily activities on a regular basis, and memory loss becomes progressively more disabling.This book is written for anyone interested in learning more about Alzheimer's disease-people who have it, their families and caregivers, professionals who serve such people, teachers, and anyone with a general interest in the disease. An important feature of this book is clear explanation of the basic biology of the disease. Here is information about who gets the disease, how it is diagnosed, and what happens to people who have it. A large section is devoted to the subject of caring for affected individuals, including legal and financial planning advice and pointers for finding outside support services. Existing treatments are discussed along with suggestions for handling many symptoms without drugs.Understanding Alzheimer's Disease describes the most current knowledge of how and why it arises and gives information about the many avenues being explored in search of a cure.With its chapters on causes and on the search for treatments, this guide will be of interest to a wider section of the population than other books on the disease.

Diseases & Physical Ailments

UNIVERSITY PRESS OF MISSISSIPPI

Alzheimer's disease has received growing attention in recent years because the affected population is growing quickly as life spans in America creep ever upward. As they near retirement, many Americans start to fear that any minor memory lapse-misplacing the keys or forgetting a name-might spell Alzheimer's. In reality such incidents are a normal part of the aging process. In Alzheimer's disease, such incidents progress to a point at which they interfere with normal daily activities on a regular basis, and memory loss becomes progressively more disabling.
This book is written for anyone interested in learning more about Alzheimer's disease-people who have it, their families and caregivers, professionals who serve such people, teachers, and anyone with a general interest in the disease. An important feature of this book is clear explanation of the basic biology of the disease. Here is information about who gets the disease, how it is diagnosed, and what happens to people who have it. A large section is devoted to the subject of caring for affected individuals, including legal and financial planning advice and pointers for finding outside support services. Existing treatments are discussed along with suggestions for handling many symptoms without drugs.
Understanding Alzheimer's Disease describes the most current knowledge of how and why it arises and gives information about the many avenues being explored in search of a cure.
With its chapters on causes and on the search for treatments, this guide will be of interest to a wider section of the population than other books on the disease.

Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials. 
The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future. Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations

Critical Pathways to Success in CNS Drug Development

Medical Books

Riordan, Henry

Biek, Peter

Pharmacology

Wiley/Blackwell

Although much is known about the progressive and degenerative illness Alzheimer's disease, very little has been learned regarding effective treatment. This study provides up to date information on the search for effective therapies.

Alzheimer's Disease: Optimizing the Development of the Next Generation of Therapeutic Compounds (Greenwich Medical Media)

Medicine

Oxford University Press

Diabetes Mellitus is estimated to affect over 124 million individuals worldwide. The rising prevalence of type 1 diabetes and the projected global increase in type 2 diabetes attests to the urgent need for the development of safer and more effective treatment strategies. This book provides an overview of the latest developments in diabetes research, and critically assesses both current therapies and potential new treatment compounds. Methodological aspects of clinical trials in diabetes and related regulatory issues are examined in detail. Key features • Written by an experienced team of authors with a proven track record in publishing for this market • Up-to-date and comprehensive coverage of recent clinical trials and research studies • Features a useful evaluation of future trends in diabetes research and treatment

Optimizing Therapeutic Development in Diabetes

Jhee, Stanford S.

Fleming, G. Alexander

Coniff, Robert F.

Riordan, Henry J.

Greenwich Medical Media

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Books by Cutler, Neal R.