Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

Principles of Animal Extrapolation (Environmental Science & Technology: A Wiley-Interscience Series of Texts and Monographs)

Medical Books

Calabrese, Edward J.

Calabnese, Edward J.

Pharmacology

John Wiley&Sons

The contamination of soils by undesirable chemical compounds is becoming an increasingly important environmental issue. This volume contains the proceedings of a conference on the effects of petroleum-contaminated soils, held at the University of Massachusetts in October 1985. Contributors from research, engineering, industry and government discussed chemistry and modelling, public and environmental health and safety, engineering remedial action and regulatory and legal aspects.

Soils Contaminated by Petroleum: Environmental and Public Health Effects

Science & Math

Biological Sciences

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Books by Calabnese, Edward J.