Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Antibacterial agents act against bacterial infection either bykilling the bacterium or by arresting its growth. They do this bytargeting bacterial DNA and its associated processes, attackingbacterial metabolic processes including protein synthesis, orinterfering with bacterial cell wall synthesis and function.Antibacterial Agents is an essential guide to this importantclass of chemotherapeutic drugs. Compounds are organised accordingto their target, which helps the reader understand the mechanism ofaction of these drugs and how resistance can arise. The book usesan integrated “lab-to-clinic” approach which coversdrug discovery, source or synthesis, mode of action, mechanisms ofresistance, clinical aspects (including links to currentguidelines, significant drug interactions, cautions andcontraindications), prodrugs and future improvements.Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazoleantibacterial agentsagents targeting metabolic processes -  sulfonamideantibacterial agents and trimethoprimagents targeting protein synthesis - aminoglycoside, macrolideand tetracycline antibiotics, chloramphenicol, andoxazolidinonesagents targeting cell wall synthesis - β-Lactam andglycopeptide antibiotics, cycloserine, isonaizid, anddaptomycinAntibacterial Agents will find a place on the bookshelvesof students of pharmacy, pharmacology, pharmaceutical sciences,drug design/discovery, and medicinal chemistry, and as a benchreference for pharmacists and pharmaceutical researchers inacademia and industry.

Science & Math

Anderson, Rosaleen

Groundwater, Paul W.

Todd, Adam

Worsley, Alan

Chemistry

wiley

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: 
<ul>
<li>agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents</li> <li>agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim</li> <li>agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones</li> <li>agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin</li> </ul>
Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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