Mitochondrial DNA Mutations in Aging, Disease and Cancer

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Mitochondrial DNA Mutations in Aging, Disease and Cancer image
ISBN-10:

3662125110

ISBN-13:

9783662125113

Edition: Softcover reprint of the original 1st ed. 1998
Released: Jan 11, 2013
Publisher: Springer
Format: Paperback, 432 pages
Related ISBN: 9781570594861

Description:

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

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