Molecular and Cellular Biology of Diabetes Mellitus (Volume 2)

The second of this three-part series shifts to the molecular biology of insulin action at the level of the cell in both normal and abnormal states. The book begins with the evolution of the insulin molecule and its receptor. Several chapters discuss the structure and function of the insulin receptor and its cellular itinerary, with particular emphasis on the importance of the insulin receptor kinase and receptor gene structure-function relationships. The book further explores these mechanisms as they relate to the cellular and molecular pathogenesis of insulin resistance, and also fully describes the trans-membrane signal for insulin action.