<p>The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as <b>epigenetics</b>, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer.</p> <p>This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described.</p> <p>The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.</p>
<br><br>

Human Epigenetics: How Science Works

Science & Math

Carlberg, Carsten

Molnár, Ferdinand

Biological Sciences

Springer

<p>About the Author\nCarsten Carlberg graduated 1989 with a PhD in biochemistry at the Free University Berlin (Germany). After positions as postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland) and docent at the University of Düsseldorf (Germany) he is since 2000 full professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present Prof. Carlberg focuses projects on epigenome-wide effects of vitamin D on the human immune system.<br />
Ferdinand Molnár received his PhD in biochemistry from the University of Kuopio (Kuopio, Finland) in 2006. He did his postdoctoral training in Structural Biology at the IGBMC (Illkirch, France). In 2008 he joined the School of Pharmacy at the University of Eastern Finland (Kuopio, Finland) studying nuclear receptor-ligand, - protein and -DNA interactions. In 2018 he moved to the Nazarbayev University (Nur-Sultan, Kazakhstan) where he holds an Associate Professor position at the Department of Biology. Prof. Molnár interests are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease and recombinant protein production.\nThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.</p>

Mechanisms of Gene Regulation: How Science Works

<p><p>The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics,&nbsp;<i>i.e.</i>, the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type&nbsp;2 diabetes, can be explained only to some 20%&nbsp;<i>via</i>&nbsp;a genetic predisposition.&nbsp;<b>We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome</b>. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but&nbsp;<b>all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine</b>. This will provide them with a good basis for their specialized disciplines of modern life science research.<br /> The book is subdivided into 42 chapters that are linked to a series of lecture courses in "Molecular Medicine and Genetics", "Molecular Immunology", "Cancer Biology" and "Nutrigenomics" that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. This book represents an updated version and fusion of the books textbooks "Mechanisms of Gene Regulation: How Science Works" (ISBN 978-3-030-52321-3), "Human Epigenetics: How Science Works" (ISBN 978-3-030-22907-8). "Molecular Immunology: How Science Works" (ISBN 978-3-031-04024-5), "Cancer Biology: How Science Works" (ISBN 978-3-030-75699-4) and "Nutrigenomics: How Science Works" (ISBN 978-3-030-36948-4). By combining basic understanding of cellular mechanism with clinical examples, the authors hope to make this textbook a personal experience. A glossary in the appendix will explain the major specialist's terms.</p></p>

Molecular Medicine: How Science Works

Velleuer, Eunike

<p>Die Ansicht ,,Es liegt alles in unseren Genen und wir können es nicht ändern" hat sich in den letzten 150 Jahren seit Gregor Mendels Experimenten mit blühenden Erbsenpflanzen entwickelt. Es gibt jedoch eine besondere Form der Genetik, die Epigenetik, bei der unsere Gene nicht verändert werden, sondern geregelt wird, wie und wann sie genutzt werden. Unsere Umwelt und Lebensstilentscheidungen beeinflussen die Epigenetik unserer Zellen und Organe, d. h. die Epigenetik verändert sich dynamisch während unseres gesamten Lebens. Wir haben also die Möglichkeit, unsere Epigenetik sowohl positiv als auch negativ zu verändern. <div><br /> <div>In diesem Buch wird auf molekularer Ebene erklärt, wie unser Genom mit Umweltsignalen verbunden ist. Es zeigt auf, dass die epigenetische Programmierung ein Lernprozess ist, der zu einem epigenetischen Gedächtnis in jeder Zelle unseres Körpers führt. Die zentrale Bedeutung der Epigenetik während der Embryogenese und der zellulären Differenzierung sowie beim Alterungsprozess und dem Risiko für die Entstehung von Krebs werden erörtert. Darüber hinaus wird die Rolle des Epigenoms als molekularer Speicher für zelluläre Ereignisse nicht nur im Gehirn, sondern auch in Stoffwechselorganen und im Immunsystem beschrieben.</div> <div><br /></div> <div>Das Buch ist die Übersetzung des Lehrbuchs ,,Human Epigenetics: How Science Works" (ISBN 978-3-030-22907-8) der Autoren. In den ersten fünf Kapiteln werden die molekularen Grundlagen der Epigenetik erläutert, während die folgenden sieben Kapitel Beispiele für die Auswirkungen der Epigenetik auf die menschliche Gesundheit und Krankheit liefern.</div> <div><br /></div> </div></p>

Epigenetik des Menschen (German Edition)

Springer Spektrum

<p>The fascinating area of Nutrigenomics describes this daily communication between diet, food and nutrients, their metabolites and our genome. This book describes how nutrition shapes human evolution and demonstrates its consequences for our susceptibility to diseases, such as diabetes and atherosclerosis. Inappropriate diet can yield stress for our cells, tissues and organs and then it is often associated with low-grade chronic inflammation. Overnutrition paired with physical inactivity leads to overweight and obesity and results in increased burden for a body that originally was adapted for a life in the savannas of East Africa. Therefore, this textbook does not discuss a theoretical topic in science, but it talks about real life, and our life-long “chat” with diet. We are all food consumers, thus each of us is concerned by the topic of this book and should be aware of its mechanisms.   </p> <p>The purpose of this book is to provide an overview on the principles of nutrigenomics and their relation to health or disease. We are not aiming to compete with more comprehensive textbooks on molecular nutrition, evolutionary biology, genomics, gene regulation or metabolic diseases, but rather will focus on the essentials and will combine, in a compact form, elements from different disciplines. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”.   </p> <p>The content of this book is based on the lecture course “Nutrigenomics”, which is held since 2003 once per year by Prof. Carlberg at the University of Eastern Finland in Kuopio. The book is subdivided into three sections and twelve chapters. Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively.     </p> <p>Besides its value as a textbook, <b>Nutrigenomics</b> will be a usefull reference for individuals working in biomedicine.         </p>

Nutrigenomics

Ulven, Stine Marie

<p>Warum verstoffwechseln wir dieselben Mahlzeiten so unterschiedlich? Haben ernährungsbedingte Erkrankungen eine genetische Ursache? Können Genuntersuchungen Vorhersagen zum Eintreten solcher Erkrankungen liefern? Welchen Einfluss haben Umwelt und Verhalten? Mit diesen und ähnlichen Fragen befasst sich das Gebiet der Nutrigenomik, das die Wechselwirkung zwischen Ernährung und Genom erforscht. <div>&nbsp; <div>Zu Beginn dieses Lehrbuchs wird ein Überblick über die Bedeutung der Nutrigenomik im Kontext der Ernährungswissenschaften gegeben. Sodann wird auf das menschliche Genom sowie seine Variationen eingegangen und der besondere Einfluss der Ernährung auf dessen Evolution beschrieben. Im Anschluss werden die molekularen Grundlagen der Wechselwirkung von Nährstoffen und anderen Nahrungsbestandteilen mit zellulären Signalnetzwerken besprochen, die die Genexpression modulieren. In drei abschließenden Kapiteln werden nutrigenomische Aspekte von Erkrankungen wie Adipositas, Diabetes und Herz-Kreislauf-Erkrankungen besprochen.&nbsp;</div> <div><br /></div> <div>Dieses Lehrbuch richtet sich an Studierende der Ernährungswissenschaften, der Biochemie und Molekularbiologie sowie der Biologie. Zahlreiche Farbabbildungen unterstützen die Wissensvermittlung, indem komplexe Abläufe grafisch zusammengefasst werden. Verbunden mit einem Glossar, das die wichtigsten Fachbegriffe erklärt, eignet sich das Werk somit ideal zur Modulbegleitung und Prüfungsvorbereitung.&nbsp;</div> <div><br /></div> </div></p>

Nutrigenomik: Gene und unsere Ernährung (German Edition)

Klotz, Lars-Oliver

<p><i>This textbook aims to describe </i>the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.</p>
<p>A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.</p>
<p>The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”.</p>
<p>The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, <i>Mechanisms of Gene Regulation </i>will be a useful reference for individuals working in biomedical laboratories.</p>

Mechanisms of Gene Regulation

Human Epigenomics

<p><p>The term <b>epigenetics</b> describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of <b>epigenomics</b>, the relation of which to human health and disease is discussed in this textbook.</p> <p>This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule "a picture tells more than thousand words".</p> <p>The content of the book is based on the lecture course "Molecular Medicine and Genetics" that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks "Mechanisms of Gene Regulation" (ISBN 978-94-017-7741-4) and "Nutrigenomics" (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13&nbsp;chapters. Following the Introduction (section&nbsp;A), section&nbsp;B will explain the molecular basis of epigenomics, while section&nbsp;C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines.</p> <p>Besides its value as a textbook,&nbsp;<b>Human Epigenomics&nbsp;</b>will be a useful reference for individuals working in biomedicine.</p></p>

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Books by Molnár, Ferdinand

See the best price to sell, buy, or rent books by Molnár, Ferdinand. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Human Epigenetics: How Science Works

Mechanisms of Gene Regulation: How Science Works

Molecular Medicine: How Science Works

Epigenetik des Menschen (German Edition)

Nutrigenomics

Nutrigenomics

Nutrigenomik: Gene und unsere Ernährung (German Edition)

Mechanisms of Gene Regulation

Human Epigenomics

Human Epigenomics