Mathematical and numerical modelling of the human cardiovascular system has attracted remarkable research interest due to its intrinsic mathematical difficulty and the increasing impact of cardiovascular diseases worldwide. This book addresses the two principal components of the cardiovascular system: arterial circulation and heart function. It systematically describes all aspects of the problem, stating the basic physical principles, analysing the associated mathematical models that comprise PDE and ODE systems, reviewing sound and efficient numerical methods for their approximation, and simulating both benchmark problems and clinically inspired problems. Mathematical modelling itself imposes tremendous challenges, due to the amazing complexity of the cardiovascular system and the need for computational methods that are stable, reliable and efficient. The final part is devoted to control and inverse problems, including parameter estimation, uncertainty quantiﬁcation and the development of reduced-order models that are important when solving problems with high complexity, which would otherwise be out of reach.

Mathematical Modelling of the Human Cardiovascular System: Data, Numerical Approximation, Clinical Applications (Cambridge Monographs on Applied and Computational Mathematics, Series Number 33)

Science & Math

Quarteroni, Alfio

Manzoni, Andrea

Dede', Luca

Vergara, Christian

Mathematics

Cambridge University Press

Optimal Control of Partial Differential Equations: Analysis, Approximation, and Applications (Applied Mathematical Sciences, 207)

This is a book on optimal control problems (OCPs) for partial differential equations (PDEs) that evolved from a series of courses taught by the authors in the last few years at Politecnico di Milano, both at the undergraduate and graduate levels. The book covers the whole range spanning from the setup and the rigorous theoretical analysis of OCPs, the derivation of the system of optimality conditions, the proposition of suitable numerical methods, their formulation, their analysis, including their application to a broad set of problems of practical relevance.The first introductory chapter addresses a handful of representative OCPs and presents an overview of the associated mathematical issues. The rest of the book is organized into three parts: part I provides preliminary concepts of OCPs for algebraic and dynamical systems; part II addresses OCPs involving linear PDEs (mostly elliptic and parabolic type) and quadratic cost functions; part III deals with more general classes of OCPs that stand behind the advanced applications mentioned above.\nStarting from simple problems that allow a “hands-on” treatment, the reader is progressively led to a general framework suitable to face a broader class of problems. Moreover, the inclusion of many pseudocodes allows the reader to easily implement the algorithms illustrated throughout the text. 
The three parts of the book are suitable to readers with variable mathematical backgrounds, from advanced undergraduate to Ph.D. levels and beyond. We believe that applied mathematicians, computational scientists, and engineers may find this book useful for a constructive approach toward the solution of OCPs in the context of complex applications.

Salsa, Sandro

Springer

This is a book on optimal control problems (OCPs) for partial differential equations (PDEs) that evolved from a series of courses taught by the authors in the last few years at Politecnico di Milano, both at the undergraduate and graduate levels. The book covers the whole range spanning from the setup and the rigorous theoretical analysis of OCPs, the derivation of the system of optimality conditions, the proposition of suitable numerical methods, their formulation, their analysis, including their application to a broad set of problems of practical relevance. The first introductory chapter addresses a handful of representative OCPs and presents an overview of the associated mathematical issues. The rest of the book is organized into three parts: part I provides preliminary concepts of OCPs for algebraic and dynamical systems; part II addresses OCPs involving linear PDEs (mostly elliptic and parabolic type) and quadratic cost functions; part III deals with more general classes ofOCPs that stand behind the advanced applications mentioned above. Starting from simple problems that allow a "hands-on" treatment, the reader is progressively led to a general framework suitable to face a broader class of problems. Moreover, the inclusion of many pseudocodes allows the reader to easily implement the algorithms illustrated throughout the text. The three parts of the book are suitable to readers with variable mathematical backgrounds, from advanced undergraduate to Ph.D. levels and beyond. We believe that applied mathematicians, computational scientists, and engineers may find this book useful for a constructive approach toward the solution of OCPs in the context of complex applications.

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