Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD. The papers include early, hardtofind classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literaturebased course on molecular cell biology. As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that "deep study of the agreedon classics is the best training for learning how to recognize those contemporary papers worthy of our personal time...."

Landmark Papers in Yeast Biology

Science & Math

Shore, David

Hall, Michael N.

Linder, Patrick

Biological Sciences

Cold Spring Harbor Laboratory Press

Yeast genetics began with Winge's 1935 studies of S. cerevisiae in Copenhagen, and afterwards was pursued by Lindegren in the U.S. and Ephrussi in France. Genetic studies in S. pombe were pioneered by Leupold in the 1940s in Switzerland. Within four decades, not without controversies, both yeast species were recognized as essential models in eukaryotic molecular cell biology. In this remarkable volume, Hall and Linder have assembled the reminiscences of many early investigators whose pioneering studies in the years before 1975 brought yeast biology to its current maturity. These illustrated essays about the science, the events and the personalities involved capture a fascinating era, in the informal style made famous by Phage and the Origins of Molecular Biology. This is a book that all scientists interested in the development of modern genetics and molecular biology should have on their shelves.

The Early Days of Yeast Genetics

Evolution

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