This Second Edition covers exciting progress recently made with individual drugs and includes a special chapter on the impact of molecular biology on drug design. Other additions to the Second Edition include structure-activity relationships, the role of molecular biology in drug discovery, and drug access and prodrugs. Written for students considering a research career in drug development, this volume is conveniently divided into two parts. The first half introduces readers to the mechanisms of action of drugs and the approaches adopted in designing new drugs. The second half contains chapters written by the discoverers or developers of individual successful drugs who trace the history of the drugs to the present day.

Medicinal Chemistry: The Role of Organic Chemistry in Drug Research

Science & Math

Roberts, Stanley M.

Ganellin, C.R.

Chemistry

Academic Press

This book provides the ultimate resource for medicinal and pharmaceutical chemists, presenting concise chemical, physical, and bibliographic data on drugs and pharmacological agents. More than 30,000 compounds are contained in 8,200 entries. Coverage includes all currently marketed drugs, pharmacological tools, bioactive natural products, and compounds in the later stages of clinical trials. The types of data provided include 
<li>entry names 
</li>
<li>synonyms indicating generic names, trade names, and company codes 
</li>
<li>accurately drawn diagrams depicting stereochemistry 
</li>
<li>approved names 
</li>
<li>trade names 
</li>
<li>molecular formulae and weight 
</li>
<li>physical properties, including melting point and/or boiling point 
</li>
<li>disassociation constant 
</li>
<li>partition coefficients - both experimental and calculated 
</li>
<li>hazard and toxicity data 
</li>
<li>patenting company 
</li>
<li>marketing/development status 
</li>
<li>therapeutic uses 
</li>
<li>mechanism of action 
</li>
<li>key literature citations 
</li>
<li>carefully selected bibliographies directing the reader straight to the primary literature Four detailed indexes help readers find exactly the information they need: Name (generic, chemical, trivial), Molecular Formula, and CAS Registry Number and Therapeutic Category (225 categories). Dictionary of Pharmacological Agents serves as the information source, comprehensively presenting essential information for medicinal chemists</li>

Dictionary of Pharmacological Agents

Reference

Triggle, David J.

Dictionaries & Thesauruses

Chapman and Hall/CRC

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